Computational models in cardiology

SA Niederer, J Lumens, NA Trayanova - Nature reviews cardiology, 2019 - nature.com
The treatment of individual patients in cardiology practice increasingly relies on advanced
imaging, genetic screening and devices. As the amount of imaging and other diagnostic …

A review of inflammatory mechanism in airway diseases

P Aghasafari, U George, R Pidaparti - Inflammation Research, 2019 - Springer
Background Inflammation in the lung is the body's natural response to injury. It acts to
remove harmful stimuli such as pathogens, irritants, and damaged cells and initiate the …

Integrated heart—coupling multiscale and multiphysics models for the simulation of the cardiac function

A Quarteroni, T Lassila, S Rossi… - Computer Methods in …, 2017 - Elsevier
Mathematical modeling of the human heart and its function can expand our understanding of
various cardiac diseases, which remain the most common cause of death in the developed …

Multi-scale simulations of cardiac electrophysiology and mechanics using the University of Tokyo heart simulator

S Sugiura, T Washio, A Hatano, J Okada… - Progress in biophysics …, 2012 - Elsevier
The importance and need for an integrative mathematical modeling approach in the
biological and medical fields is currently well recognized. Such an approach is crucial in …

A numerical study of scalable cardiac electro-mechanical solvers on HPC architectures

P Colli Franzone, LF Pavarino, S Scacchi - Frontiers in physiology, 2018 - frontiersin.org
We introduce and study some scalable domain decomposition preconditioners for cardiac
electro-mechanical 3D simulations on parallel HPC (High Performance Computing) …

Computational modeling for cardiac resynchronization therapy

AWC Lee, CM Costa, M Strocchi, CA Rinaldi… - Journal of …, 2018 - Springer
Cardiac resynchronization therapy (CRT) is an effective treatment for heart failure (HF)
patients with an electrical substrate pathology causing ventricular dyssynchrony. However …

Patient-specific modelling of cardiac electrophysiology in heart-failure patients

M Potse, D Krause, W Kroon, R Murzilli, S Muzzarelli… - Europace, 2014 - academic.oup.com
Aims Left-ventricular (LV) conduction disturbances are common in heart-failure patients and
a left bundle-branch block (LBBB) electrocardiogram (ECG) type is often seen. The precise …

Optimization of cardiac resynchronization therapy based on a cardiac electromechanics-perfusion computational model

L Fan, JS Choy, F Raissi, GS Kassab, LC Lee - Computers in biology and …, 2022 - Elsevier
Cardiac resynchronization therapy (CRT) is an established treatment for left bundle branch
block (LBBB) resulting in mechanical dyssynchrony. Approximately 1/3 of patients with CRT …

Organ‐level validation of a cross‐bridge cycling descriptor in a left ventricular finite element model: effects of ventricular loading on myocardial strains

SM Shavik, ST Wall, J Sundnes, D Burkhoff… - Physiological …, 2017 - Wiley Online Library
Although detailed cell‐based descriptors of cross‐bridge cycling have been applied in finite
element (FE) heart models to describe ventricular mechanics, these multiscale models have …

Influence of left ventricular lead position relative to scar location on response to cardiac resynchronization therapy: a model study

PR Huntjens, J Walmsley, S Ploux, P Bordachar… - Europace, 2014 - academic.oup.com
Aims It is unclear how the position of the left ventricular (LV) lead relative to a scar affects the
haemodynamic response in patients with dyssynchronous heart failure receiving cardiac …