Sepsis affects practically all aspects of endothelial cell (EC) function and is thought to be the
key factor in the progression from sepsis to organ failure. Endothelial functions affected by …

Acute kidney injury causes significant morbidity and mortality in the community and clinic.
Various pathologies, including renal and cardiovascular disease, traumatic …

The pathogenesis of sepsis-associated acute kidney injury is complex and likely involves
perfusion alterations, a dysregulated inflammatory response, and bioenergetic …

Acute kidney injury (AKI) is a complication of sepsis and leads to a high mortality rate.
Human and animal studies suggest that mitochondrial dysfunction plays an important role in …

The mortality rate of patients who develop acute kidney injury during sepsis nearly doubles.
The effectiveness of therapy is hampered because it is usually initiated only after the onset …

To investigate the role of oxidative stress and/or mitochondrial impairment in the occurrence
of acute kidney injury (AKI) during sepsis, we developed a sepsis-induced in vitro model …

Acute kidney injury is a frequent and serious complication of sepsis. To better understand
the development of sepsis-induced acute kidney injury, we performed the first time …

Peroxynitrite is a reactive oxidant produced from nitric oxide and superoxide, which reacts
with proteins, lipids, and DNA, and promotes cytotoxic and proinflammatory responses …

Increasing evidence demonstrates that reactive oxygen species plays important roles in
sepsis-induced acute kidney injury. This study investigated the effects of VitD3 pretreatment …

The renal microvasculature is emerging as a key player in acute and chronic kidney
diseases. Renal microvascular disease involves alterations in endothelial barrier …