A mechanistic understanding of aging has yet to be described; this paper puts forth a new
theory that has the potential to explain aging in all sexually reproductive life forms. The …

Research studies clearly indicate that age-related changes in cellular and tissue function
are linked to decreases in the anabolic hormones, growth hormone and insulin-like growth …

GH participates in growth, metabolism, and cellular differentiation. To study these roles, we
previously generated two different dwarf mouse lines, one expressing a GH antagonist …

SUMMARY A negative intraspecific relationship between growth and longevity was
proposed in the early 20th century. Indeed, stunting the growth of rodents by restricting their …

Insulin/insulin-like growth factor (IGF) signaling plays a major role in thecontrol of aging and
life span ininvertebrates. Major extension of life span ingrowth hormone receptor knock out …

Cells, Aging, and Human Disease is the first book to explore aging all the way from genes to
clinical application, analyzing the fundamental cellular changes which underlie human age …

The remarkable progress in understanding the genetic basis of life-span determination in
invertebrates indicates that impairments in the insulin–insulin-like growth factor 1 (IGF-1) …

Two muscle insulinlike growth factorI (IGFI) mRNA splice variants (IGFIEa and IGFIEb)
have been identified in rodents. IGFIEb, also called mechano growth factor (MGF) has been …

Caloric restriction (CR) initiated in young rodents has been thoroughly documented to
enhance longevity, but its efficacy when introduced at older ages has not been well …

Regulated animal growth occurred following a single electroporated injection of a mixture of
two plasmids (10 μg of DNA), one expressing the GeneSwitch™ regulator protein, the other …