Digital twins in pharmaceutical and biopharmaceutical manufacturing: a literature review

Y Chen, O Yang, C Sampat, P Bhalode… - Processes, 2020 - mdpi.com
The development and application of emerging technologies of Industry 4.0 enable the
realization of digital twins (DT), which facilitates the transformation of the manufacturing …

Application of PAT-based feedback control approaches in pharmaceutical crystallization

Y Gao, T Zhang, Y Ma, F Xue, Z Gao, B Hou, J Gong - Crystals, 2021 - mdpi.com
Crystallization is one of the important unit operations for the separation and purification of
solid products in the chemical, pharmaceutical, and pesticide industries, especially for …

A critical review on thermodynamic and hydrodynamic modeling and simulation of liquid antisolvent crystallization of pharmaceutical compounds

AK Thakur, R Kumar, VKV Kumar, A Kumar… - Journal of Molecular …, 2022 - Elsevier
Fine particles are in great demand in the pharmaceutical industry due to their versatile
applications. Liquid antisolvent crystallization (LASC) is one of the promising approaches to …

Control of antisolvent mass transfer through porous membranes for the crystallization of organic compounds

S Chergaoui, DP Debecker, T Leyssens… - Crystal Growth & …, 2023 - ACS Publications
Crystallization faces great challenges from the point of view of technology readiness,
process economics, and energy consumption. Membranes are capable of controlling both …

Revealing the effects of microwell sizes on the crystal growth kinetics of active pharmaceutical ingredients by deep learning

J He, J Zhou, J Dong, Z Su, L Huang - Chemical Engineering Journal, 2022 - Elsevier
In the pharmaceutical industry, high-throughput crystallization (HTC) is an emerging strategy
to accelerate the discovery of active pharmaceutical ingredients (APIs) with appropriate …

Cross-pharma collaboration for the development of a simulation tool for the model-based digital design of pharmaceutical crystallization processes (CrySiV)

B Szilagyi, WL Wu, A Eren, J Mackey… - Crystal Growth & …, 2021 - ACS Publications
Precompetitive collaborations on new enabling technologies for research and development
are becoming popular among pharmaceutical companies. The Enabling Technologies …

Single crystal perovskite an emerging photocatalytic and storage material: Synthesis to applications via theoretical insight

N Priyadarshini, S Mansingh, KK Das, R Mohanty… - Physics Reports, 2024 - Elsevier
The utilization of solar energy through artificial photocatalysis has emerged as a potential
candidate to tackle the surging energy crisis and staggering environmental pollution. The …

Kinetics and population balance modeling of antisolvent crystallization of polymorphic indomethacin

L Yang, Y Zhang, P Liu, C Wang, Y Qu, J Cheng… - Chemical Engineering …, 2022 - Elsevier
This work focuses on an important problem that is the modeling and control of polymorphic
crystallization of indomethacin (IMC) in which one of the crystal forms consists of hair-like …

Recent advances in the monitoring of protein crystallization processes in downstream processing

B Walla, D Bischoff, I Corona Viramontes… - Crystals, 2023 - mdpi.com
Protein crystallization is nowadays performed at the micro to macro scale in academia and
industry, being particularly interesting for pharmaceutical applications. Protein crystallization …

Risk-based operation of a continuous mixed-suspension-mixed-product-removal antisolvent crystallization process for polymorphic control

I Ostergaard, HL De Diego, H Qu… - … Process Research & …, 2020 - ACS Publications
Innovations in the continuous crystallization field are required for the pharmaceutical
industry to go through the paradigm shift from batch to continuous processing. To do so …