Digital twins in pharmaceutical and biopharmaceutical manufacturing: a literature review
The development and application of emerging technologies of Industry 4.0 enable the
realization of digital twins (DT), which facilitates the transformation of the manufacturing …
realization of digital twins (DT), which facilitates the transformation of the manufacturing …
Application of PAT-based feedback control approaches in pharmaceutical crystallization
Crystallization is one of the important unit operations for the separation and purification of
solid products in the chemical, pharmaceutical, and pesticide industries, especially for …
solid products in the chemical, pharmaceutical, and pesticide industries, especially for …
A critical review on thermodynamic and hydrodynamic modeling and simulation of liquid antisolvent crystallization of pharmaceutical compounds
Fine particles are in great demand in the pharmaceutical industry due to their versatile
applications. Liquid antisolvent crystallization (LASC) is one of the promising approaches to …
applications. Liquid antisolvent crystallization (LASC) is one of the promising approaches to …
Control of antisolvent mass transfer through porous membranes for the crystallization of organic compounds
Crystallization faces great challenges from the point of view of technology readiness,
process economics, and energy consumption. Membranes are capable of controlling both …
process economics, and energy consumption. Membranes are capable of controlling both …
Revealing the effects of microwell sizes on the crystal growth kinetics of active pharmaceutical ingredients by deep learning
J He, J Zhou, J Dong, Z Su, L Huang - Chemical Engineering Journal, 2022 - Elsevier
In the pharmaceutical industry, high-throughput crystallization (HTC) is an emerging strategy
to accelerate the discovery of active pharmaceutical ingredients (APIs) with appropriate …
to accelerate the discovery of active pharmaceutical ingredients (APIs) with appropriate …
Cross-pharma collaboration for the development of a simulation tool for the model-based digital design of pharmaceutical crystallization processes (CrySiV)
Precompetitive collaborations on new enabling technologies for research and development
are becoming popular among pharmaceutical companies. The Enabling Technologies …
are becoming popular among pharmaceutical companies. The Enabling Technologies …
Single crystal perovskite an emerging photocatalytic and storage material: Synthesis to applications via theoretical insight
The utilization of solar energy through artificial photocatalysis has emerged as a potential
candidate to tackle the surging energy crisis and staggering environmental pollution. The …
candidate to tackle the surging energy crisis and staggering environmental pollution. The …
Kinetics and population balance modeling of antisolvent crystallization of polymorphic indomethacin
L Yang, Y Zhang, P Liu, C Wang, Y Qu, J Cheng… - Chemical Engineering …, 2022 - Elsevier
This work focuses on an important problem that is the modeling and control of polymorphic
crystallization of indomethacin (IMC) in which one of the crystal forms consists of hair-like …
crystallization of indomethacin (IMC) in which one of the crystal forms consists of hair-like …
Recent advances in the monitoring of protein crystallization processes in downstream processing
B Walla, D Bischoff, I Corona Viramontes… - Crystals, 2023 - mdpi.com
Protein crystallization is nowadays performed at the micro to macro scale in academia and
industry, being particularly interesting for pharmaceutical applications. Protein crystallization …
industry, being particularly interesting for pharmaceutical applications. Protein crystallization …
Risk-based operation of a continuous mixed-suspension-mixed-product-removal antisolvent crystallization process for polymorphic control
I Ostergaard, HL De Diego, H Qu… - … Process Research & …, 2020 - ACS Publications
Innovations in the continuous crystallization field are required for the pharmaceutical
industry to go through the paradigm shift from batch to continuous processing. To do so …
industry to go through the paradigm shift from batch to continuous processing. To do so …