Prior to the first successful bone marrow transplant in 1968, patients born with severe
combined immunodeficiency (SCID) invariably died. Today, with a widening availability of …

Abstract Severe Combined Immunodeficiency (SCID) is the most profound inborn error of
immunity affecting cellular and humoral immunity. Hematopoietic stem cell transplantation …

The mature lymphocyte population of a healthy individual has the remarkable ability to
recognise an immense variety of antigens. Instead of encoding a unique gene for each …

Human papillomaviruses (HPVs) are responsible for cutaneous and mucosal lesions.
Persistent HPV infection remains a leading cause of uterine cancer in women, but also of …

Purpose While neonatal bloodspot screening (NBS) for severe combined immunodeficiency
(SCID) has been introduced more than a decade ago, implementation in NBS programs …

Combined immunodeficiencies are a heterogeneous collection of primary immune disorders
that exhibit defects in T cell development or function, along with impaired B cell activity even …

Varicella zoster virus (VZV) is a pathogenic human herpes virus which causes varicella as a
primary infection, following which it becomes latent in peripheral autonomic, sensory, and …

Human papillomaviruses (HPVs) infect mucosal or cutaneous stratified epithelia. There are
5 genera and more than 200 types of HPV, each with a specific tropism and virulence. HPV …

Severe combined immunodeficiencies (SCIDs) are a group of inborn errors of the immune
system, usually associated with severe or life-threatening infections. Due to the variability of …

Background Implementation of newborn screening (NBS) programs for severe combined
immunodeficiency (SCID) have advanced the diagnosis and management of affected infants …