Clinical history, questionnaire data and response to antisecretory therapy are insufficient to
make a conclusive diagnosis of GERD in isolation, but are of value in determining need for …

Gastroesophageal reflux disease (GERD) is a condition in which gastric contents regurgitate
into the esophagus or beyond, resulting in either troublesome symptoms or complications …

Functional esophageal disorders consist of a disease category that presents with
esophageal symptoms (heartburn, chest pain, dysphagia, globus) that are not explained by …

Background The introduction of proton pump inhibitors (PPIs) into clinical practice has
revolutionized the management of acid-related diseases. Studies in primary care and …

This document serves as an update of the North American Society for Pediatric
Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for …

The advent of powerful acid-suppressive drugs, such as proton pump inhibitors (PPIs), has
revolutionized the management of acid-related diseases and has minimized the role of …

Background & Aims Analyses of impedance parameters such as the post-reflux swallow-
induced peristaltic wave (PSPW) index and the mean nocturnal baseline impedance (MNBI) …

Background Gastroesophageal reflux disease (GERD) is one of the most frequent benign
disorders of the upper gastrointestinal tract. Management of GERD has always been …

GERD is a common condition worldwide. Key mechanisms of disease include abnormal
oesophagogastric junction structure and function, and impaired oesophageal clearance. A …

Introduction: The introduction of proton pump inhibitors (PPIs) into clinical practice has
greatly improved our therapeutic approach to acid-related diseases for their efficacy and …