Background Hypersensitive esophagus (HE) is defined by endoscopy-negative heartburn
with a normal acid exposure time but positive symptom association probability (SAP) and/or …

Gastro-esophageal reflux disease (GERD) is a highly prevalent, chronic disorder, whose
knowledge remains limited and the management of these patients changes continuously …

Gastroesophageal reflux disease (GERD) is a condition that develops when the reflux of
gastric contents into the esophagus leads to troublesome symptoms and/or complications …

Heartburn is the most specific symptom of gastroesophageal reflux disease (GERD). In
clinical practice, heartburn relief by a proton pump inhibitor (PPI) trial does suffice to confirm …

The Montreal definition of gastroesophageal reflux disease (GERD) provided a rationale for
acid suppression medication without investigation, thus enhancing the management of the …

Patients with esophageal symptoms potentially associated to esophageal motor disorders
such as dysphagia, chest pain, heartburn and regurgitation, represent one of the most …

Background & Aims Patients with functional esophageal disorders present with symptoms of
chest pain, heartburn, dysphagia, or globus in the absence of any structural abnormality …

Background High‐resolution manometry (HRM) provides information on esophagogastric
junction (EGJ) morphology, distinguishing three different subtypes. Data on the correlation …

Gastroesophageal reflux disease (GERD) and idiopathic pulmonary fibrosis (IPF) are two
pathological conditions often strictly related, even if a clear relationship of causality has not …

Esophageal motility abnormalities are among the main factors implicated in the
pathogenesis of gastroesophageal reflux disease. The recent introduction in clinical and …