The potential role of potassium-competitive acid blockers in the treatment of gastroesophageal reflux disease

C Scarpignato, RH Hunt - Current opinion in gastroenterology, 2019 - journals.lww.com
The potential role of potassium-competitive acid blockers in... : Current Opinion in
Gastroenterology The potential role of potassium-competitive acid blockers in the treatment of …

Between GERD and NERD: the relevance of weakly acidic reflux

N de Bortoli, A Ottonello, F Zerbib… - Annals of the New …, 2016 - Wiley Online Library
Nonerosive reflux disease (NERD) is a common condition and the most frequent phenotype
of gastroesophageal reflux disease (GERD). NERD is extremely heterogeneous and …

Appropriateness in prescribing PPIs: a position paper of the Italian Society of Gastroenterology (SIGE)—study section “digestive diseases in primary care”

V Savarino, C Tosetti, E Benedetto, D Compare… - Digestive and Liver …, 2018 - Elsevier
The introduction of proton pump inhibitors (PPIs) into clinical practice about thirty years ago
has greatly improved our therapeutic approach to acid-related diseases for their well …

Role of TRPV 1 receptor in inflammation and impairment of esophageal mucosal integrity in a murine model of nonerosive reflux disease

RO Silva, RD Bingana, T Sales… - …, 2018 - Wiley Online Library
Background Microscopic inflammation and impairment of the esophageal epithelial barrier
are considered relevant for perception of symptoms in patients with nonerosive reflux …

Recent insights on functional heartburn and reflux hypersensitivity

E Savarino, E Marabotto… - Current Opinion in …, 2022 - journals.lww.com
The better ability to interpret impedance-pH tracings together with earlier data on the
different prevalence of microscopic esophagitis in RH and FH patients, and recent studies …

[HTML][HTML] Application of artificial intelligence in measuring novel pH-impedance metrics for optimal diagnosis of GERD

MW Wong, BD Rogers, MX Liu, WY Lei, TT Liu, CH Yi… - Diagnostics, 2023 - mdpi.com
Novel metrics extracted from pH-impedance monitoring can augment the diagnosis of
gastroesophageal reflux disease (GERD). Artificial intelligence (AI) is being widely used to …

Diagnosis and management of functional heartburn

C Hachem, NJ Shaheen - Official journal of the American College …, 2016 - journals.lww.com
Heartburn is among the most common gastrointestinal symptoms presenting to both
generalist physicians and gastroenterologists. Heartburn that does not respond to traditional …

[HTML][HTML] Drugs for improving esophageal mucosa defense: where are we now and where are we going?

E Savarino, P Zentilin, E Marabotto… - Annals of …, 2017 - ncbi.nlm.nih.gov
In the past, the attention of physiologists and doctors has been mainly focused on the key
role of acid in the pathogenesis of gastroesophageal reflux disease (GERD), but increasing …

Advancements in the use of 24-hour impedance-pH monitoring for GERD diagnosis

E Marabotto, V Savarino, M Ghisa, M Frazzoni… - Current Opinion in …, 2022 - Elsevier
Gastro-esophageal reflux disease (GERD) occurs in about 25% of the general population.
The complexity of the disease and the multiplicity of its clinical manifestations impair the …

[HTML][HTML] Pepsin in saliva as a diagnostic marker for gastroesophageal reflux disease: a meta-analysis

Z Guo, H Wu, J Jiang, C Zhang - Medical science monitor …, 2018 - ncbi.nlm.nih.gov
Background Gastroesophageal reflux disease (GERD) is very common. Salivary pepsin
detection has previously been considered as a method for GERD diagnosis. We performed …