[HTML][HTML] Preliminary evidence for the presence of multiple forms of cell death in diabetes cardiomyopathy

J Wei, Y Zhao, H Liang, W Du, L Wang - Acta Pharmaceutica Sinica B, 2022 - Elsevier
Diabetic mellitus (DM) is a common degenerative chronic metabolic disease often
accompanied by severe cardiovascular complications (DCCs) as major causes of death in …

[HTML][HTML] Diabetic cardiomyopathy: Early diagnostic biomarkers, pathogenetic mechanisms, and therapeutic interventions

JL Huo, Q Feng, S Pan, WJ Fu, Z Liu, Z Liu - Cell death discovery, 2023 - nature.com
Diabetic cardiomyopathy (DCM) mainly refers to myocardial metabolic dysfunction caused
by high glucose, and hyperglycemia is an independent risk factor for cardiac function in the …

Trimetazidine protects against myocardial ischemia/reperfusion injury by inhibiting excessive autophagy

S Wu, G Chang, L Gao, D Jiang, L Wang, G Li… - Journal of Molecular …, 2018 - Springer
Trimetazidine (TMZ) has been demonstrated to have protective effects against myocardial
ischemia/reperfusion (MI/R) injury. In the present study, we investigated the effects and the …

[HTML][HTML] Metabolic regulation to treat bipolar depression: mechanisms and targeting by trimetazidine

S Khanra, P Reddy, A Giménez-Palomo… - Molecular …, 2023 - nature.com
Bipolar disorder's core feature is the pathological disturbances in mood, often accompanied
by disrupted thinking and behavior. Its complex and heterogeneous etiology implies that a …

[HTML][HTML] Trimetazidine in heart failure

H Shu, Y Peng, W Hang, N Zhou… - Frontiers in …, 2021 - frontiersin.org
Heart failure is a systemic syndrome caused by multiple pathological factors. Current
treatments do not have satisfactory outcomes. Several basic studies have revealed the …

MECHANISMS IN ENDOCRINOLOGY: Diabetic cardiomyopathy: pathophysiology and potential metabolic interventions state of the art review

E Levelt, G Gulsin, S Neubauer… - European journal of …, 2018 - academic.oup.com
Heart failure is a major cause of morbidity and mortality in type 2 diabetes. Type 2 diabetes
contributes to the development of heart failure through a variety of mechanisms, including …

[HTML][HTML] The role of ERK1/2 in the development of diabetic cardiomyopathy

Z Xu, J Sun, Q Tong, Q Lin, L Qian, Y Park… - International Journal of …, 2016 - mdpi.com
Diabetes mellitus is a chronic metabolic condition that affects carbohydrate, lipid and protein
metabolism and may impair numerous organs and functions of the organism. Cardiac …

[HTML][HTML] Is autophagy associated with diabetes mellitus and its complications? A review

D Bhattacharya, M Mukhopadhyay… - EXCLI …, 2018 - ncbi.nlm.nih.gov
Diabetes mellitus (DM) is an endocrine disorder. In coming decades it will be one of the
leading causes of death globally. The key factors in the pathogenesis of diabetes are …

[HTML][HTML] Trimetazidine attenuates exhaustive exercise-induced myocardial injury in rats via regulation of the Nrf2/NF-κB signaling pathway

H Zhang, M Liu, Y Zhang, X Li - Frontiers in pharmacology, 2019 - frontiersin.org
Exhausted exercise has been reported to cause the damage of myocardial structure and
function in terms of cardiomyocyte apoptosis, oxidative stress, and energy metabolism …

[HTML][HTML] The mystery of diabetic cardiomyopathy: from early concepts and underlying mechanisms to novel therapeutic possibilities

P Grubić Rotkvić, Z Planinić, AM Liberati Pršo… - International journal of …, 2021 - mdpi.com
Diabetic patients are predisposed to diabetic cardiomyopathy, a specific form of
cardiomyopathy which is characterized by the development of myocardial fibrosis …