The overriding goal of the treatment of patients is its effectiveness and safety. However, all
medications currently being used also exert some adverse pharmaceutical reactions, which …

Ageing is a complex process characterized mainly by a decline in the function of cells,
tissues, and organs, resulting in an increased risk of mortality. This process involves several …

Objectives Exogenous mitochondria transplantation or mitotherapy can be used to swap out
unhealthy mitochondria for functioning ones. Treatment of mitochondrial diseases using this …

The patients with kidney diseases are increasing rapidly all over the world. With the rich
abundance of mitochondria, kidney is an organ with a high consumption of energy. Hence …

Chronic kidney disease (CKD) affects 10% of the population. Fibrosis is the hallmark of
CKD, which is marked by the deposit of extracellular matrix (ECM). This response is the final …

Cisplatin-induced nephrotoxicity restricts its clinical use against solid tumors. The present
study elucidated the pharmacological effects of Renogrit, a plant-derived prescription …

The mechanism of indomethacin toxicity at the systemic level is largely unknown. In this
study, multi-specimen molecular characterization was conducted in rats treated with three …

Ifosfamide (IFO) kidney damage is an important organ toxicity in children and adults
undergoing chemotherapy. Previous evidence has shown that IFO toxic metabolites such as …

The kidney is more susceptible to poisoning than any other organ in the body because of the
number of poisons that are delivered to it. By 2040, it is anticipated that kidney diseases will …

In recent years, preclinical research on diabetic kidney disease (DKD) has surged to the
forefront of scientific and clinical attention. DKD has become a pervasive complication of …