Background Substance use disorder (SUD) remains a significant public health issue. A
greater understanding of how genes and environment interact to regulate phenotypes …

Abstract Purpose of Review With the advent of the genome-wide association study (GWAS),
our understanding of the genetics of addiction has made significant strides forward. Here …

Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately
heritable traits. We conduct genome-wide association studies of these traits using …

Liability to alcohol dependence (AD) is heritable, but little is known about its complex
polygenic architecture or its genetic relationship with other disorders. To discover loci …

Objective: Alcohol use disorders are common conditions that have enormous social and
economic consequences. Genome-wide association analyses were performed to identify …

Alcohol consumption has been linked to over 200 diseases and is responsible for over 5%
of the global disease burden. Well-known genetic variants in alcohol metabolizing genes, for …

Alcohol consumption is a complex trait determined by both genetic and environmental
factors, and is correlated with the risk of alcohol use disorders. Although a small number of …

Genetic factors contribute to the risk for developing alcohol use disorder (AUD). In
collaboration with the genetics company 23andMe, Inc., we performed a genome‐wide …

Background Habitual alcohol use can be an indicator of alcohol dependence, which is
associated with a wide range of serious health problems. Methods We completed a genome …

Cocaine dependence is a complex psychiatric disorder that is highly comorbid with other
psychiatric traits. Twin and adoption studies suggest that genetic variants contribute …