Improving outcomes of tyrosine kinase inhibitors in hepatocellular carcinoma: new data and ongoing trials
L Mou, X Tian, B Zhou, Y Zhan, J Chen, Y Lu… - Frontiers in …, 2021 - frontiersin.org
Targeted therapies such as oral tyrosine kinase inhibitors (TKIs) are the main therapeutic
strategy effective for advanced hepatocellular carcinoma (HCC). Currently six tyrosine …
strategy effective for advanced hepatocellular carcinoma (HCC). Currently six tyrosine …
Recent advances in boosting EGFR tyrosine kinase inhibitors-based cancer therapy
Q Pan, Y Lu, L Xie, D Wu, R Liu, W Gao… - Molecular …, 2023 - ACS Publications
Epidermal growth factor receptor (EGFR) plays a key role in signal transduction pathways
associated with cell proliferation, growth, and survival. Its overexpression and aberrant …
associated with cell proliferation, growth, and survival. Its overexpression and aberrant …
Nanocomposite systems for precise oral delivery of drugs and biologics
Oral delivery is considered the favoured route of administration for both local and systemic
delivery of active molecules. Formulation of drugs in conventional systems and …
delivery of active molecules. Formulation of drugs in conventional systems and …
Exosomal delivery of cannabinoids against cancer
Exosomes are extracellular vesicles (EVs) originating from endosomes that play a role in
cellular communication. These vesicles which mimic the parental cells that release them are …
cellular communication. These vesicles which mimic the parental cells that release them are …
The role of Cannabidiol and tetrahydrocannabivarin to overcome doxorubicin resistance in MDA-MB-231 xenografts in athymic nude mice
The significant resistance to currently available chemotherapeutics makes treatment for
TNBC a key clinical concern. Herein, we studied the anti-cancer potentials of synthetic …
TNBC a key clinical concern. Herein, we studied the anti-cancer potentials of synthetic …
Erlotinib entrapped in cholesterol-depleting cyclodextrin nanoparticles shows improved antitumoral efficacy in 3D spheroid tumors of the lung and the liver
Erlotinib (ERL), a tyrosine kinase inhibitor approved for therapeutic use in non-small cell
lung cancer is further researched for eventual liver cancer treatment. However, conventional …
lung cancer is further researched for eventual liver cancer treatment. However, conventional …
Exploring the role of self-nanoemulsifying systems in drug delivery: challenges, issues, applications and recent advances
Nanotechnology has attracted researchers around the globe owing to the small size and
targeting properties of the drug delivery vectors. The interest in self-nanoemulsifying drug …
targeting properties of the drug delivery vectors. The interest in self-nanoemulsifying drug …
Self-Generating nano-emulsification techniques for alternatively-routed, bioavailability enhanced delivery, especially for anti-cancers, anti-diabetics, and …
The self-generating nano-emulsifying drug delivery system (SNEDDS) is among the most
effective approaches to enhance the oral bioavailability of a therapeutic agent, especially of …
effective approaches to enhance the oral bioavailability of a therapeutic agent, especially of …
Self-emulsifying drug delivery system for oral anticancer therapy: Constraints and recent development
M Pandya, B Chatterjee, S Ganti - Current Pharmaceutical …, 2022 - ingentaconnect.com
Oral anticancer therapy faces several drawbacks: low aqueous solubility, poor and irregular
absorption from gastrointestinal sites, high first-pass metabolism, food-influenced …
absorption from gastrointestinal sites, high first-pass metabolism, food-influenced …
[图书][B] Smart drug-delivery nanostructured systems for cancer therapy
Cancer is the second most common cause of death worldwide. It was estimated that about
9.6 million people died of cancer in 2018 (Bray et al., 2018). Various treatment options have …
9.6 million people died of cancer in 2018 (Bray et al., 2018). Various treatment options have …