BACKGROUND Although narrative reviews have concluded that there is strong support for
familial clustering of prostate carcinoma, the association has never systematically been …

Prostate cancer is the most frequent cancer among men in most developed countries, yet
little is known about its causes. Older age, African ancestry and a positive family history of …

Studies on familial aggregation of cancer may suggest an overall contribution of inherited
genes or a shared environment in the development of malignant disease. We performed a …

An increased risk of prostate cancer associated with a family history of prostate cancer has
been documented in multiple published reports. Risk has been shown to vary by degree of …

Rapid advances in positional cloning studies have identified most of the genes on the
human Y chromosome, thereby providing resources for studying the expression of its genes …

Approximately 5–10% of prostate cancer cases are caused by dominantly inherited
susceptibility to the disease. Although advances have been made in research concerning …

Segregation analyses aim to detect genetic factors that have a major effect on an individual's
risk of disease and to describe them in terms of mode of inheritance, age-specific cumulative …

The objectives of this study were to investigate the effect of family history on prostate cancer
risk, to estimate the incidence of hereditary prostate cancer in southern Sweden and to …

Prostate cancer is usually heterogeneous and multifocal, with diverse clinical and
morphologic manifestations. Current understanding of the molecular basis for this …

We analysed the relation between family history of cancer in first‐degree relatives and risk of
prostate cancer (PC) and benign prostatic hyperplasia (BPH) using data from a multicentric …