Skull bone marrow channels as immune gateways to the central nervous system
Decades of research have characterized diverse immune cells surveilling the CNS. More
recently, the discovery of osseous channels (so-called 'skull channels') connecting the …
recently, the discovery of osseous channels (so-called 'skull channels') connecting the …
The path to leptomeningeal metastasis
The leptomeninges, the cerebrospinal-fluid-filled tissues surrounding the central nervous
system, play host to various pathologies including infection, neuroinflammation and …
system, play host to various pathologies including infection, neuroinflammation and …
The covariance environment defines cellular niches for spatial inference
A key challenge of analyzing data from high-resolution spatial profiling technologies is to
suitably represent the features of cellular neighborhoods or niches. Here we introduce the …
suitably represent the features of cellular neighborhoods or niches. Here we introduce the …
Development of a triple-negative breast cancer leptomeningeal disease model in Zebrafish
Leptomeningeal disease occurs when cancer cells migrate into the ventricles of the brain
and spinal cord and then colonize the meninges of the central nervous system. The triple …
and spinal cord and then colonize the meninges of the central nervous system. The triple …
Therapies beyond Physiological Barriers and Drug Resistance: A Pilot Study and Review of the Literature Investigating If Intrathecal Trastuzumab and New Treatment …
OG Trifănescu, D Mitrea, LN Galeș, A Ciornei… - Cancers, 2023 - mdpi.com
Simple Summary Approximately 10% of HER2-positive breast cancer patients will develop
leptomeningeal metastases (LM), characterized by the spread of tumor cells within the …
leptomeningeal metastases (LM), characterized by the spread of tumor cells within the …
Mechanical filtration of the cerebrospinal fluid: procedures, systems, and applications
M Menéndez González - Expert Review of Medical Devices, 2023 - Taylor & Francis
Introduction Mechanical methods aimed at the filtration of the cerebrospinal fluid (CSF) are a
group of therapies that have been proposed to treat neurological conditions where …
group of therapies that have been proposed to treat neurological conditions where …
Cerebrospinal fluid‐dissemination of a ovarian clear cell carcinoma: A leptomeningial carcinomatosis with diagnostic challenges
A Koyuncuer, E Varol… - Diagnostic …, 2023 - Wiley Online Library
Metastases from ovarian cancer to the central nervous system (CNS) are rare, in particular,
isolated leptomeningeal metastases (LM) are extremely rare. The gold standard in the …
isolated leptomeningeal metastases (LM) are extremely rare. The gold standard in the …
The potential of liquorpheresis to treat leptomeningeal disease.
Leptomeningeal disease (LMD) is a devastating sequela of many cancers with an extremely
poor prognosis. Barriers to improving outcomes are related to the inability for many …
poor prognosis. Barriers to improving outcomes are related to the inability for many …
New strategies for the treatment of breast cancer with leptomeningeal metastasis
SM Chew, AD Seidman - Current Opinion in Oncology, 2023 - journals.lww.com
New strategies for the treatment of breast cancer with lepto... : Current Opinion in Oncology
New strategies for the treatment of breast cancer with leptomeningeal metastasis : Current …
New strategies for the treatment of breast cancer with leptomeningeal metastasis : Current …
Ventriculoperitoneal shunting with an on–off valve for patients with leptomeningeal metastases and intracranial hypertension
KM Huntoon, J Gasco, IC Glitza Oliva… - Neuro-Oncology …, 2024 - academic.oup.com
Background We report our experience with using a ventriculoperitoneal shunt (VPS) with an
on–off valve and in-line Ommaya reservoir for the treatment of hydrocephalus or intracranial …
on–off valve and in-line Ommaya reservoir for the treatment of hydrocephalus or intracranial …