The respiratory tree maintains sterilizing immunity against human fungal pathogens.
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …

Fungal infections represent a serious global health problem, causing damage to health and
the economy on the scale of millions. Although vaccines are the most effective therapeutic …

Aspergillus fumigatus causes invasive aspergillosis (IA) in immunocompromised patients,
resulting in high mortality rates. Currently, no vaccine formulations to promote immune …

We previously reported that administration of Cryptococcus neoformans Δsgl1 mutant
vaccine, accumulating sterylglucosides (SGs) and having normal capsule (GXM), protects …

Systemic infection with Cryptococcus neoformans, a dangerous and contagious pathogen
found throughout the world, frequently results in lethal cryptococcal pneumonia and …

Cryptococcosis is a mycosis caused by Cryptococcus neoformans and C. gattii species
complexes. Although this infection is potentially lethal, no prophylactic vaccine is yet …

Prophylactic vaccination strategies designed to prevent diseases caused by pathogens
using the phagolysosome of innate immune cells as a site of intracellular replication and …

In previous studies, we determined that the F-box protein Fbp1, a subunit of the SCF (Fbp1)
E3 ligase in Cryptococcus neoformans, is essential for fungal pathogenesis. Heat-killed …

The emergence of Cryptococcus neoformans has posed an undeniable burden to many
regions worldwide, with its strains mainly entering the lungs through the respiratory tract and …

Systemic cryptococcosis is fatal without treatment. Even with the current antifungal therapies,
this disease kills 180,000 of 225,000 infected people annually. Exposure to the causative …