Immunity to fungi in the lung
LJ Heung, DL Wiesner, K Wang, A Rivera… - Seminars in immunology, 2023 - Elsevier
The respiratory tree maintains sterilizing immunity against human fungal pathogens.
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …
Humans inhale ubiquitous filamentous molds and geographically restricted dimorphic fungal …
Fungal vaccine development: State of the art and perspectives using Immunoinformatics
MM Inácio, ALE Moreira, VRM Cruz-Leite, K Mattos… - Journal of Fungi, 2023 - mdpi.com
Fungal infections represent a serious global health problem, causing damage to health and
the economy on the scale of millions. Although vaccines are the most effective therapeutic …
the economy on the scale of millions. Although vaccines are the most effective therapeutic …
[HTML][HTML] Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling
TG Normile, TH Chu, BS Sheridan, M Del Poeta - Mucosal immunology, 2022 - Elsevier
We previously reported that administration of Cryptococcus neoformans Δsgl1 mutant
vaccine, accumulating sterylglucosides (SGs) and having normal capsule (GXM), protects …
vaccine, accumulating sterylglucosides (SGs) and having normal capsule (GXM), protects …
Vaccination with Live or Heat-Killed Aspergillus fumigatus ΔsglA Conidia Fully Protects Immunocompromised Mice from Invasive Aspergillosis
CM Fernandes, TG Normile, JHTM Fabri, VS Brauer… - MBio, 2022 - Am Soc Microbiol
Aspergillus fumigatus causes invasive aspergillosis (IA) in immunocompromised patients,
resulting in high mortality rates. Currently, no vaccine formulations to promote immune …
resulting in high mortality rates. Currently, no vaccine formulations to promote immune …
Vaccination with a ZNF2oe Strain of Cryptococcus Provides Long-Lasting Protection against Cryptococcosis and Is Effective in Immunocompromised Hosts
Systemic cryptococcosis is fatal without treatment. Even with the current antifungal therapies,
this disease kills 180,000 of 225,000 infected people annually. Exposure to the causative …
this disease kills 180,000 of 225,000 infected people annually. Exposure to the causative …
Immunization with a heat-killed prm1 deletion strain protects the host from Cryptococcus neoformans infection
C Li, Y Meng, H Li, W Du, X Gao, C Suo… - Emerging Microbes & …, 2023 - Taylor & Francis
Systemic infection with Cryptococcus neoformans, a dangerous and contagious pathogen
found throughout the world, frequently results in lethal cryptococcal pneumonia and …
found throughout the world, frequently results in lethal cryptococcal pneumonia and …
Development of a Heat-Killed fbp1 Mutant Strain as a Therapeutic Agent To Treat Invasive Cryptococcus Infection
In previous studies, we determined that the F-box protein Fbp1, a subunit of the SCF (Fbp1)
E3 ligase in Cryptococcus neoformans, is essential for fungal pathogenesis. Heat-killed …
E3 ligase in Cryptococcus neoformans, is essential for fungal pathogenesis. Heat-killed …
Promising whole‐cell vaccines against cryptococcosis
K Ueno, S Tsuge, K Shimizu… - Microbiology and …, 2023 - Wiley Online Library
Cryptococcosis is a mycosis caused by Cryptococcus neoformans and C. gattii species
complexes. Although this infection is potentially lethal, no prophylactic vaccine is yet …
complexes. Although this infection is potentially lethal, no prophylactic vaccine is yet …
[HTML][HTML] Design of a cryptococcus neoformans vaccine by subtractive proteomics combined with immunoinformatics
F Zhu, Z Zhou, S Ma, Y Xu, C Tan, H Yang… - International …, 2024 - Elsevier
The emergence of Cryptococcus neoformans has posed an undeniable burden to many
regions worldwide, with its strains mainly entering the lungs through the respiratory tract and …
regions worldwide, with its strains mainly entering the lungs through the respiratory tract and …
Inbred Mouse Models in Cryptococcus neoformans Research
M Ding, K Nielsen - Journal of Fungi, 2024 - mdpi.com
Animal models are frequently used as surrogates to understand human disease. In the
fungal pathogen Cryptococcus species complex, several variations of a mouse model of …
fungal pathogen Cryptococcus species complex, several variations of a mouse model of …