Allodynia (pain due to a stimulus that does not usually provoke pain) and hyperalgesia
(increased pain from a stimulus that usually provokes pain) are prominent symptoms in …

Pain is fundamentally unpleasant, a feature that protects the organism by promoting
motivation and learning. Relief of aversive states, including pain, is rewarding. The …

Central sensitization (CS), simply defined as an amplified response of the central nervous
system to peripheral input, is a concept of great importance in clinical medicine. It has …

Chinese prickly ash is known for producing a typical pungent sensation in Sichuan Cuisine.
Accumulating evidence suggest a series of health benefits and pharmacological effects …

Patients with spinal cord injury (SCI) may experience several types of chronic pain, including
peripheral and central neuropathic pain, pain secondary to overuse, painful muscle spasms …

Pain can trigger central amplification called central sensitization, which ultimately results in
hyperalgesia and/or allodynia. Many reports have showed acupuncture has an analgesic …

The use of bioengineered nerve guides as alternatives for autologous nerve transplantation
(ANT) is a promising strategy for the repair of peripheral nerve defects. In the present …

Nearly every surgery can elicit a rather therapy-resistant chronic postoperative pain.
Preventive medicine is therefore anticipated with hopeful eyes, but requires a better …

We hypothesized that local delivery of GDNF in spinal cord lesion via an injectable alginate
hydrogel gelifying in situ would support spinal cord plasticity and functional recovery. The …

In the spinal nerve ligation (SNL) model of neuropathic pain, as in other pain models,
abnormal spontaneous activity of myelinated sensory neurons occurs early and is essential …