[HTML][HTML] Mitochondria as a cellular hub in infection and inflammation

P Andrieux, C Chevillard, E Cunha-Neto… - International journal of …, 2021 - mdpi.com
Mitochondria are the energy center of the cell. They are found in the cell cytoplasm as
dynamic networks where they adapt energy production based on the cell's needs. They are …

Chagas cardiomyopathy: an update of current clinical knowledge and management: a scientific statement from the American Heart Association

MCP Nunes, A Beaton, H Acquatella, C Bern… - Circulation, 2018 - Am Heart Assoc
Background: Chagas disease, resulting from the protozoan Trypanosoma cruzi, is an
important cause of heart failure, stroke, arrhythmia, and sudden death. Traditionally …

Trypanosoma cruzi genetic diversity: Something new for something known about Chagas disease manifestations, serodiagnosis and drug sensitivity

B Zingales - Acta tropica, 2018 - Elsevier
The genetic diversity of Trypanosoma cruzi, the protozoan agent of Chagas disease, is
widely recognized. At present, T. cruzi is partitioned into seven discrete typing units (DTUs) …

[HTML][HTML] Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

MC Field, D Horn, AH Fairlamb… - Nature Reviews …, 2017 - nature.com
The WHO recognizes human African trypanosomiasis, Chagas disease and the
leishmaniases as neglected tropical diseases. These diseases are caused by parasitic …

[HTML][HTML] Endothelial to mesenchymal transition (EndoMT) in the pathogenesis of human fibrotic diseases

S Piera-Velazquez, FA Mendoza… - Journal of clinical …, 2016 - mdpi.com
Fibrotic diseases encompass a wide spectrum of clinical entities including systemic fibrotic
diseases such as systemic sclerosis, sclerodermatous graft versus host disease …

Current drug therapy and pharmaceutical challenges for Chagas disease

J Bermudez, C Davies, A Simonazzi, JP Real, S Palma - Acta tropica, 2016 - Elsevier
One of the most significant health problems in the American continent in terms of human
health, and socioeconomic impact is Chagas disease, caused by the protozoan parasite …

Chronic Chagas heart disease management: from etiology to cardiomyopathy treatment

EA Bocchi, RB Bestetti, MI Scanavacca… - Journal of the American …, 2017 - jacc.org
Trypanosoma cruzi (T. cruzi) infection is endemic in Latin America and is becoming a
worldwide health burden. It may lead to heterogeneous phenotypes. Early diagnosis of T …

[HTML][HTML] Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole …

A Rassi Jr, JA Marin, A Rassi - Memórias do Instituto Oswaldo Cruz, 2017 - SciELO Brasil
Chagas cardiomyopathy is the most frequent and most severe manifestation of chronic
Chagas disease, and is one of the leading causes of morbidity and death in Latin America …

[HTML][HTML] Long QT syndrome: an emerging role for inflammation and immunity

PE Lazzerini, PL Capecchi… - Frontiers in cardiovascular …, 2015 - frontiersin.org
The long QT syndrome (LQTS), classified as congenital or acquired, is a multi-factorial
disorder of myocardial repolarization predisposing to life-threatening ventricular …

[HTML][HTML] Increased mortality attributed to Chagas disease: a systematic review and meta-analysis

ZM Cucunubá, O Okuwoga, MG Basáñez… - Parasites & vectors, 2016 - Springer
Background The clinical outcomes associated with Chagas disease remain poorly
understood. In addition to the burden of morbidity, the burden of mortality due to …