[HTML][HTML] Co-exposure of cardiomyocytes to IFN-γ and TNF-α induces mitochondrial dysfunction and nitro-oxidative stress: implications for the pathogenesis of chronic …
JPS Nunes, P Andrieux, P Brochet… - Frontiers in …, 2021 - frontiersin.org
Infection by the protozoan Trypanosoma cruzi causes Chagas disease cardiomyopathy
(CCC) and can lead to arrhythmia, heart failure and death. Chagas disease affects 8 million …
(CCC) and can lead to arrhythmia, heart failure and death. Chagas disease affects 8 million …
[HTML][HTML] SBC guideline on the diagnosis and treatment of patients with cardiomyopathy of chagas disease–2023
JA Marin-Neto, A Rassi Jr, GMM Oliveira… - Arquivos Brasileiros …, 2023 - SciELO Brasil
SciELO - Brazil - Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com
Cardiomiopatia da Doença de Chagas – 2023 Diretriz da SBC sobre Diagnóstico e Tratamento …
Cardiomiopatia da Doença de Chagas – 2023 Diretriz da SBC sobre Diagnóstico e Tratamento …
[HTML][HTML] Resveratrol reverses functional Chagas heart disease in mice
G Vilar-Pereira, VC Carneiro, H Mata-Santos… - PLoS …, 2016 - journals.plos.org
Chronic chagasic cardiomyopathy (CCC) develops years after acute infection by
Trypanosoma cruzi and does not improve after trypanocidal therapy, despite reduction of …
Trypanosoma cruzi and does not improve after trypanocidal therapy, despite reduction of …
[HTML][HTML] miRNAs may play a major role in the control of gene expression in key pathobiological processes in Chagas disease cardiomyopathy
L Laugier, LRP Ferreira, FM Ferreira… - PLoS neglected …, 2020 - journals.plos.org
Chronic Chagas disease cardiomyopathy (CCC), an especially aggressive inflammatory
dilated cardiomyopathy caused by lifelong infection with the protozoan Trypanosoma cruzi …
dilated cardiomyopathy caused by lifelong infection with the protozoan Trypanosoma cruzi …
[HTML][HTML] Challenges in Chagas disease drug development
AF Francisco, S Jayawardhana, F Olmo, MD Lewis… - Molecules, 2020 - mdpi.com
The protozoan parasite Trypanosoma cruzi causes Chagas disease, an important public
health problem throughout Latin America. Current therapeutic options are characterised by …
health problem throughout Latin America. Current therapeutic options are characterised by …
Developments in the management of Chagas cardiomyopathy
HB Tanowitz, FS Machado, DC Spray… - Expert review of …, 2015 - Taylor & Francis
Over 100 years have elapsed since the discovery of Chagas disease and there is still much
to learn regarding pathogenesis and treatment. Although there are antiparasitic drugs …
to learn regarding pathogenesis and treatment. Although there are antiparasitic drugs …
Chemokines and heart disease: a network connecting cardiovascular biology to immune and autonomic nervous systems
V Dusi, A Ghidoni, A Ravera… - Mediators of …, 2016 - Wiley Online Library
Among the chemokines discovered to date, nineteen are presently considered to be relevant
in heart disease and are involved in all stages of cardiovascular response to injury …
in heart disease and are involved in all stages of cardiovascular response to injury …
Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy
Host and parasite diversity are suspected to be key factors in Chagas disease pathogenesis.
Experimental investigation of underlying mechanisms is hampered by a lack of tools to …
Experimental investigation of underlying mechanisms is hampered by a lack of tools to …
[HTML][HTML] Cytokine networks as targets for preventing and controlling Chagas heart disease
CC Koh, EGA Neves, TG de Souza-Silva, AC Carvalho… - Pathogens, 2023 - mdpi.com
Chagas disease, a neglected disease caused by the protozoan Trypanosoma cruzi, is
endemic in 21 Latin American countries, affecting 6–8 million people. Increasing numbers of …
endemic in 21 Latin American countries, affecting 6–8 million people. Increasing numbers of …
[HTML][HTML] Circulating miRNAs as potential biomarkers associated with cardiac remodeling and fibrosis in chagas disease cardiomyopathy
Chagas disease (CD) affects approximately 6–7 million people worldwide, from which 30%
develop chronic Chagas cardiomyopathy (CCC), usually after being asymptomatic for years …
develop chronic Chagas cardiomyopathy (CCC), usually after being asymptomatic for years …