[HTML][HTML] Co-exposure of cardiomyocytes to IFN-γ and TNF-α induces mitochondrial dysfunction and nitro-oxidative stress: implications for the pathogenesis of chronic …

JPS Nunes, P Andrieux, P Brochet… - Frontiers in …, 2021 - frontiersin.org
Infection by the protozoan Trypanosoma cruzi causes Chagas disease cardiomyopathy
(CCC) and can lead to arrhythmia, heart failure and death. Chagas disease affects 8 million …

[HTML][HTML] SBC guideline on the diagnosis and treatment of patients with cardiomyopathy of chagas disease–2023

JA Marin-Neto, A Rassi Jr, GMM Oliveira… - Arquivos Brasileiros …, 2023 - SciELO Brasil
SciELO - Brazil - Diretriz da SBC sobre Diagnóstico e Tratamento de Pacientes com
Cardiomiopatia da Doença de Chagas – 2023 Diretriz da SBC sobre Diagnóstico e Tratamento …

[HTML][HTML] Resveratrol reverses functional Chagas heart disease in mice

G Vilar-Pereira, VC Carneiro, H Mata-Santos… - PLoS …, 2016 - journals.plos.org
Chronic chagasic cardiomyopathy (CCC) develops years after acute infection by
Trypanosoma cruzi and does not improve after trypanocidal therapy, despite reduction of …

[HTML][HTML] miRNAs may play a major role in the control of gene expression in key pathobiological processes in Chagas disease cardiomyopathy

L Laugier, LRP Ferreira, FM Ferreira… - PLoS neglected …, 2020 - journals.plos.org
Chronic Chagas disease cardiomyopathy (CCC), an especially aggressive inflammatory
dilated cardiomyopathy caused by lifelong infection with the protozoan Trypanosoma cruzi …

[HTML][HTML] Challenges in Chagas disease drug development

AF Francisco, S Jayawardhana, F Olmo, MD Lewis… - Molecules, 2020 - mdpi.com
The protozoan parasite Trypanosoma cruzi causes Chagas disease, an important public
health problem throughout Latin America. Current therapeutic options are characterised by …

Developments in the management of Chagas cardiomyopathy

HB Tanowitz, FS Machado, DC Spray… - Expert review of …, 2015 - Taylor & Francis
Over 100 years have elapsed since the discovery of Chagas disease and there is still much
to learn regarding pathogenesis and treatment. Although there are antiparasitic drugs …

Chemokines and heart disease: a network connecting cardiovascular biology to immune and autonomic nervous systems

V Dusi, A Ghidoni, A Ravera… - Mediators of …, 2016 - Wiley Online Library
Among the chemokines discovered to date, nineteen are presently considered to be relevant
in heart disease and are involved in all stages of cardiovascular response to injury …

Host and parasite genetics shape a link between Trypanosoma cruzi infection dynamics and chronic cardiomyopathy

MD Lewis, AF Francisco, MC Taylor… - Cellular …, 2016 - Wiley Online Library
Host and parasite diversity are suspected to be key factors in Chagas disease pathogenesis.
Experimental investigation of underlying mechanisms is hampered by a lack of tools to …

[HTML][HTML] Cytokine networks as targets for preventing and controlling Chagas heart disease

CC Koh, EGA Neves, TG de Souza-Silva, AC Carvalho… - Pathogens, 2023 - mdpi.com
Chagas disease, a neglected disease caused by the protozoan Trypanosoma cruzi, is
endemic in 21 Latin American countries, affecting 6–8 million people. Increasing numbers of …

[HTML][HTML] Circulating miRNAs as potential biomarkers associated with cardiac remodeling and fibrosis in chagas disease cardiomyopathy

CKV Nonaka, CT Macêdo, BRR Cavalcante… - International journal of …, 2019 - mdpi.com
Chagas disease (CD) affects approximately 6–7 million people worldwide, from which 30%
develop chronic Chagas cardiomyopathy (CCC), usually after being asymptomatic for years …