Investigations into intracellular replication and differentiation of Trypanosoma cruzi within
the mammalian host have been restricted by limitations in our ability to detect parasitized …

Objectives: Review the risk factors for developing cardiomegaly. Describe the typical
presentation of a patient with cardiomegaly. Summarize the treatment considerations in a …

In this study, we evaluated the long-term efficacy of a two-component subunit vaccine
against Trypanosoma cruzi infection. C57BL/6 mice were immunized with TcG2/TcG4 …

Chronic Chagas disease cardiomyopathy (CCC) is the most frequent and severe form of this
parasitic disease. CCC is caused by a progressive inflammation in the heart, resulting in …

Chronic Chagas cardiomyopathy (CCC) is one of the leading causes of morbidity and
mortality due to cardiovascular disorders in endemic areas of Chagas disease (CD), a …

Introduction Understanding compartmentalized immune responses in target organs is
crucial for elucidating the pathogenesis of various diseases. However, obtaining samples …

Galectins are differentially expressed in a variety of cell types, including immune cells, and
characterized by the affinity for β-galactoside–containing glycans. There are fifteen galectin …

Background Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and is
a serious public health problem throughout Latin America. With 6 million people infected …

Benznidazole (Bzl), the drug of choice in many countries for the treatment of Chagas
disease, leads to parasite clearance in the early stages of infection and contributes to …

Protozoan diseases cause great harm in animal husbandry and require human-provided
medical treatment. Protozoan infection can induce changes in cyclooxygenase-2 (COX-2) …