Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host-Parasite Interactions

MC Taylor, AF Francisco, S Jayawardhana… - T. cruzi Infection …, 2019 - Springer
Trypanosoma cruzi is the causative agent of Chagas disease, the most important parasitic
infection in Latin America. Despite a global research effort, there have been no significant …

Therapeutic Efficacy of a Subunit Vaccine in Controlling Chronic Trypanosoma cruzi Infection and Chagas Disease Is Enhanced by Glutathione Peroxidase Over …

S Gupta, C Smith, S Auclair, ADJ Delgadillo, NJ Garg - PloS one, 2015 - journals.plos.org
Trypanosoma cruz i-induced oxidative and inflammatory responses are implicated in
chagasic cardiomyopathy. In this study, we examined the therapeutic utility of a subunit …

Interleukin-9 in Immunopathology of Trypanosoma cruzi Experimental Infection

NSL Silva, CM Orikaza, FR Santana… - Frontiers in Cellular …, 2021 - frontiersin.org
Chagas' disease is a parasitosis caused by Trypanosoma cruzi, which affects approximately
8 million people worldwide. The balance between pro-and anti-inflammatory cytokines …

Chagas disease-related mortality in Spain, 1997 to 2018

JM Ramos-Rincon, J Llenas-García… - Microorganisms, 2021 - mdpi.com
Background. Chagas disease (CD) is associated with excess mortality in infected people in
endemic countries, but little information is available in non-endemic countries. The aim of …

IL18 Gene Variants Influence the Susceptibility to Chagas Disease

DA Leon Rodriguez, FD Carmona… - PLoS neglected …, 2016 - journals.plos.org
Chagas disease is a parasitic disorder caused by the infection with the flagellated protozoan
Trypanosoma cruzi. According to the World Health Organization, more than six million …

Chagas disease: an unknown and neglected disease

RB de Oliveira, C Ballart, A Abràs, M Gállego… - Chagas disease: a …, 2020 - Springer
Chagas disease, formerly confined to the Latin-American sub-continent, is now diagnosed in
vast numbers of T. cruzi chronically infected individuals living in the United States, Canada …

In vivo biological evaluation of a synthetic royleanone derivative as a promising fast-acting trypanocidal agent by inducing mitochondrial-dependent necrosis

R Martin-Escolano, JJ Guardia… - Journal of Natural …, 2020 - ACS Publications
The life-long and life-threatening Chagas disease is one of the most neglected tropical
diseases caused by the protozoan parasite Trypanosoma cruzi. It is a major public health …

Using hospital discharge database to characterize Chagas disease evolution in Spain: there is a need for a systematic approach towards disease detection and …

Z Herrador, E Rivas, A Gherasim… - PLoS neglected …, 2015 - journals.plos.org
After the United States, Spain comes second in the list of countries receiving migrants from
Latin America, and, therefore, it is the European country with the highest expected number of …

Doxycycline and Benznidazole Reduce the Profile of Th1, Th2, and Th17 Chemokines and Chemokine Receptors in Cardiac Tissue from Chronic Trypanosoma cruzi …

G Paula Costa, LR Lopes, MC Silva… - Mediators of …, 2016 - Wiley Online Library
Chemokines (CKs) and chemokine receptors (CKR) promote leukocyte recruitment into
cardiac tissue infected by the Trypanosoma cruzi. This study investigated the long‐term …

Association of IL18 genetic polymorphisms with Chagas disease in Latin American populations

M Strauss, M Acosta-Herrera, A Alcaraz… - PLoS Neglected …, 2019 - journals.plos.org
Host genetic factors have been suggested to play an important role in the susceptibility to
Chagas disease. Given the influence of interleukin 18 (IL-18) in the development of the …