Tanshinone IIA ameliorates experimental diabetic cardiomyopathy by inhibiting endoplasmic reticulum stress in cardiomyocytes via SIRT1

S Wu, D Lu, B Gajendran, Q Hu, J Zhang… - Phytotherapy …, 2023 - Wiley Online Library
Diabetic cardiomyopathy (DCM) is a common complication in patients with diabetes, and
ultimately leads to heart failure. Endoplasmic reticulum stress (ERS) induced by abnormal …

Sirtuins modulation: a promising strategy for HIV-associated neurocognitive impairments

I Figarola-Centurión, M Escoto-Delgadillo… - International Journal of …, 2022 - mdpi.com
HIV-Associated neurocognitive disorder (HAND) is one of the major concerns since it
persists in 40% of this population. Nowadays, HAND neuropathogenesis is considered to be …

Nutraceutical Prevention of Diabetic Complications—Focus on Dicarbonyl and Oxidative Stress

MF McCarty, JJ DiNicolantonio, JH O'Keefe - Current Issues in Molecular …, 2022 - mdpi.com
Oxidative and dicarbonyl stress, driven by excess accumulation of glycolytic intermediates in
cells that are highly permeable to glucose in the absence of effective insulin activity, appear …

Protective effect of Astragaloside IV on chronic intermittent hypoxia-induced vascular endothelial dysfunction through the calpain-1/SIRT1/AMPK signaling pathway

F Zhao, Y Meng, Y Wang, S Fan, Y Liu… - Frontiers in …, 2022 - frontiersin.org
Vascular endothelial dysfunction (VED) is linked with the pathogenesis of obstructive sleep
apnea (OSA) comorbidities, such as cardiovascular disease. Astragaloside IV (As-IV) has …

[HTML][HTML] Integration of network pharmacology, transcriptomics and molecular docking reveals two novel hypoglycemic components in snow chrysanthemum

Q Lv, X Wu, Y Guan, J Lin, Y Sun, M Hu, P Xiao… - Biomedicine & …, 2023 - Elsevier
Our previous studies uncovered the glucose-lowering properties of snow chrysanthemum
tea, however, the active ingredients and underlying mechanisms were yet to be uncovered …

The combination of natural molecules naringenin, hesperetin, curcumin, polydatin and quercetin synergistically decreases SEMA3E expression levels and DPPIV …

ES Scarpa, C Giordani, A Antonelli, M Petrelli… - International Journal of …, 2023 - mdpi.com
Type 2 diabetes mellitus (T2DM) is a disease characterized by a prolonged hyperglycemic
condition caused by insulin resistance mechanisms in muscle and liver, reduced insulin …

[HTML][HTML] Exploring the Significance of Gut Microbiota in Diabetes Pathogenesis and Management—A Narrative Review

E Młynarska, J Wasiak, A Gajewska, G Steć, J Jasińska… - Nutrients, 2024 - mdpi.com
Type 2 diabetes is a disease with significant health consequences for the individual.
Currently, new mechanisms and therapeutic approaches that may affect this disease are …

[HTML][HTML] New advances on pathophysiology of diabetes neuropathy and pain management: potential role of melatonin and DPP-4 inhibitors

P Busa, Y Kuthati, N Huang, CS Wong - Frontiers in pharmacology, 2022 - frontiersin.org
Pre-diabetes and diabetes are growing threats to the modern world. Diabetes mellitus (DM)
is associated with comorbidities such as hypertension (83.40%), obesity (90.49%), and …

An Insight into the Pathogenesis of Diabetic Cardiomyopathy Along with the Novel Potential Therapeutic Approaches

H Vig, R Ap, HN Vishwas, S Tyagi… - Current Diabetes …, 2024 - ingentaconnect.com
Background: The existence of aberrant myocardial activity and function in the exclusion of
those other cardiovascular events, such as atherosclerosis, hypertension, and severe valve …

[HTML][HTML] Hypoglycemic effect and the mechanism of action of a polysaccharide from sweet corncob in a high-fat diet and streptozotocin-induced diabetic mice

X Wang, W Xiu, Y Han, Z Wang, Y Luo, Y Ma - Food Science and Human …, 2024 - Elsevier
Type 2 diabetes mellitus (T2DM) is a metabolic disease caused by a glycolipid metabolism
disorder and islet β-cell dysfunction. SCP-80-I is a biologically active water-soluble …