The NLRP3 inflammasome is a multimeric cytosolic protein complex that assembles in
response to cellular perturbations. This assembly leads to the activation of caspase-1, which …

Inflammasomes are molecular platforms that assemble upon sensing various intracellular
stimuli. Inflammasome assembly leads to activation of caspase 1, thereby promoting the …

Background Pyroptosis is a new programmed cell death discovered in recent years.
Pyroptosis plays an important role in various diseases. Nevertheless, there are few …

Akkermansia muciniphila has been proved to play a crucial role in the progression of colitis,
but its underlying mechanism remains inconclusive. In this study, we aim to investigate the …

A fundamental concept in immunology is that the innate immune system initiates or instructs
downstream adaptive immune responses. Inflammasomes are central players in innate …

NLRP3 inflammasome can be widely found in epithelial cells and immune cells. The NOD-
like receptors (NLRs) family member NLRP3 contains a central nucleotide-binding and …

The immune system plays a critical role in shaping all facets of cancer, from the early
initiation stage through to metastatic disease and resistance to therapy. Our understanding …

Background The endoglycosidase heparanase which degrades heparan sulfate
proteoglycans, exerts a pro-inflammatory mediator in various inflammatory disorders …

The NOD-like receptor protein 3 (NLRP3) inflammasome is a protein complex that regulates
innate immune responses by activating caspase-1 and the inflammatory cytokines …

Inflammation is a protective reaction activated in response to detrimental stimuli, such as
dead cells, irritants or pathogens, by the evolutionarily conserved immune system and is …