In vitro differentiation of human pluripotent stem cells (hPSCs) into specialized tissues and
organs represents a powerful approach to gain insight into those cellular and molecular …

The lens is an avascular organ that is supported by an internal circulation of water and
solutes. This circulation is driven by ion pumps, channels and transporters in epithelial cells …

Over 35 years ago the cell biology community was introduced to connexins as the subunit
employed to assemble semicrystalline clusters of intercellular channels that had been well …

Gap junctions are specialized regions of the plasma membrane containing clusters of
channels that provide for the diffusion of ions and small molecules between adjacent cells. A …

Anomalies in protein–protein interactions may lead to a diseased state, as many cellular
functions are sustained by such interactions. These abnormal situations usually arise when …