[Frontiers in Bioscience 16, 1733-1745, January 1, 2011] 1733 Oxidative stress and endothelial
dysfunction in cerebrovascular di Page 1 [Frontiers in Bioscience 16, 1733-1745, January 1 …

Endothelial cells exert an enormous influence on blood vessels throughout the circulation,
but their impact is particularly pronounced in the brain. New concepts have emerged …

Insulin deficiency or resistance can promote dementia and hallmarks of Alzheimer's disease
(AD). The formation of neurofibrillary tangles of p-TAU protein, extracellular Aβ plaques, and …

Diabetes is not only an endocrine but also a vascular disease. Cardiovascular complications
are the leading cause of morbidity and mortality associated with diabetes. Diabetes affects …

Here we overview the role of reactive nitrogen species (nitrosative stress) and associated
pathways in the pathogenesis of diabetic vascular complications. Increased extracellular …

Cerebral small vessel disease (SVD) is a major contributor to stroke, and a leading cause of
cognitive impairment and dementia. Despite the devastating effects of cerebral SVD, the …

The systemic and cerebral microcirculation contribute critically to regulation of local and
global blood flow and perfusion pressure. Microvascular dysfunction, commonly seen in …

Cerebral small vessel disease (CSVD) is a wide term describing the condition affecting
perforating arterial branches as well as arterioles, venules, and capillaries. Cerebral …

Objective: Our goal was to identify the role of oxidative stress via activation of NAD (P) H
oxidase in cerebrovascular dysfunction in aged rats. Methods: We examined the reactivity of …

Metabolic diseases including obesity, insulin resistance and diabetes have profound effects
on cerebral circulation. These diseases not only affect the architecture of cerebral blood …