[HTML][HTML] Microglia in neurological diseases: a road map to brain-disease dependent-inflammatory response
S Bachiller, I Jiménez-Ferrer, A Paulus… - Frontiers in cellular …, 2018 - frontiersin.org
Microglia represent a specialized population of macrophages-like cells in the central
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …
nervous system (CNS) considered immune sentinels that are capable of orchestrating a …
Frontotemporal dementia
J Bang, S Spina, BL Miller - The Lancet, 2015 - thelancet.com
Frontotemporal dementia is an umbrella clinical term that encompasses a group of
neurodegenerative diseases characterised by progressive deficits in behaviour, executive …
neurodegenerative diseases characterised by progressive deficits in behaviour, executive …
[HTML][HTML] Progranulin induces immune escape in breast cancer via up-regulating PD-L1 expression on tumor-associated macrophages (TAMs) and promoting CD8+ T …
W Fang, T Zhou, H Shi, M Yao, D Zhang, H Qian… - Journal of Experimental …, 2021 - Springer
Background Progranulin (PGRN), as a multifunctional growth factor, is overexpressed in
multiple tumors, but the role of PGRN on tumor immunity is still unclear. Here, we studied the …
multiple tumors, but the role of PGRN on tumor immunity is still unclear. Here, we studied the …
[HTML][HTML] Novel Approaches for the Treatment of Alzheimer's and Parkinson's Disease
M Van Bulck, A Sierra-Magro, J Alarcon-Gil… - International journal of …, 2019 - mdpi.com
Neurodegenerative disorders affect around one billion people worldwide. They can arise
from a combination of genomic, epigenomic, metabolic, and environmental factors. Aging is …
from a combination of genomic, epigenomic, metabolic, and environmental factors. Aging is …
The lysosomal function of progranulin, a guardian against neurodegeneration
Progranulin (PGRN), encoded by the GRN gene in humans, is a secreted growth factor
implicated in a multitude of processes ranging from regulation of inflammation to wound …
implicated in a multitude of processes ranging from regulation of inflammation to wound …
Autophagy induction by trehalose: Molecular mechanisms and therapeutic impacts
K Hosseinpour‐Moghaddam… - Journal of cellular …, 2018 - Wiley Online Library
The balance between synthesis and degradation is crucial to maintain cellular homeostasis
and different mechanisms are known to keep this balance. In this review, we will provide a …
and different mechanisms are known to keep this balance. In this review, we will provide a …
[HTML][HTML] Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies
Background Converging evidence suggests that immune-mediated dysfunction plays an
important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic …
important role in the pathogenesis of frontotemporal dementia (FTD). Although genetic …
Linking deregulation of non-coding RNA to the core pathophysiology of Alzheimer's disease: An integrative review
MJ Millan - Progress in neurobiology, 2017 - Elsevier
The human genome encodes a vast repertoire of protein non-coding RNAs (ncRNA), some
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …
specific to the brain. MicroRNAs, which interfere with the translation of target mRNAs, are of …
Progranulin in neurodegenerative disease
TL Petkau, BR Leavitt - Trends in neurosciences, 2014 - cell.com
Loss-of-function mutations in the progranulin gene are a common cause of familial
frontotemporal dementia (FTD). The purpose of this review is to summarize the role of …
frontotemporal dementia (FTD). The purpose of this review is to summarize the role of …
Progranulin: a new avenue towards the understanding and treatment of neurodegenerative disease
BP Chitramuthu, HPJ Bennett, A Bateman - Brain, 2017 - academic.oup.com
Progranulin, a secreted glycoprotein, is encoded in humans by the single GRN gene.
Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 …
Progranulin consists of seven and a half, tandemly repeated, non-identical copies of the 12 …