Progranulin is a widely expressed, cysteine-rich, secreted glycoprotein originally discovered
for its growth factor-like properties. Its subsequent identification as a causative gene for …

This study assessed the therapeutic utility of the autophagy enhancing stable disaccharide
trehalose in the Tg2576 transgenic mouse model of Alzheimer's disease (AD) via an oral …

Immune dysregulation has been identified as a critical cause of the most common types of
cardiovascular diseases (CVDs). Notably, the innate and adaptive immune responses under …

Neurodegenerative dementias are clinically heterogeneous, progressive diseases with
frequently overlapping symptoms, such as cognitive impairments and behavior and …

Frontotemporal dementia (FTD) is an entity that includes a group of neurodegenerative
disease with symptoms predominantly pertaining to deficits in behavior, executive function …

Objective: To conduct a meta-analysis that investigates sex differences in the prevalence of
mutations in the 3 most common genes that cause amyotrophic lateral sclerosis (ALS) and …

Adeno-associated virus-mediated gene replacement is emerging as a safe and effective
means of correcting single-gene mutations affecting the CNS. AAV-mediated progranulin …

Loss of function of progranulin (PGRN), encoded by the granulin (GRN) gene, is implicated
in several neurodegenerative diseases. Several therapeutics to boost PGRN levels are …

Early-onset, familial Alzheimer's disease (AD) is rare and may be attributed to disease-
causinq mutations. By contrast, late onset, sporadic (non-Mendelian) AD is far more …

Progranulin (PGRN) haploinsufficiency associated with loss-of-function mutations in the
granulin gene causes frontotemporal dementia (FTD). This suggests that increasing PGRN …