Cytokines of the transforming growth factor β (TGF-β) family, including TGF-βs, bone
morphogenic proteins (BMPs), activins, and Nodal, play crucial roles in embryonic …

Embryos and developing organs have the remarkable ability of self-regenerating after
experimental manipulations. In the Xenopus blastula half-embryos can regenerate the …

The transforming growth factor β (TGF-β) family signaling pathway is conserved and
ubiquitous in animals. In Drosophila, fewer representatives of each signaling component are …

Mutations that disrupt function of the human inwardly rectifying potassium channel KIR2. 1
are associated with the craniofacial and digital defects of Andersen-Tawil Syndrome, but the …

In the mid-1960s, bone morphogenetic proteins (BMPs) were first identified in the extracts of
bone to have the remarkable ability to induce heterotopic bone. When the Drosophila gene …

At the Drosophila NMJ, BMP signaling is critical for synapse growth and homeostasis.
Signaling by the BMP7 homolog, Gbb, in motor neurons triggers a canonical pathway …

BMPs pattern the dorsal–ventral axis of vertebrate embryos. Smad1/5/8 transduces the BMP
signal, and receives phosphorylation inputs from both MAPK and GSK3. Phosphorylation of …

Schwank et al. challenge the temporal growth model with an experiment in which Dpp signal
transduction is abrogated. They claim that in this condition, cellular Dpp signaling levels do …

Cell proliferation is dependent on growth factors insulin and IGF1. We sought to identify
interactors of IRS1, the most proximal mediator of insulin/IGF1 signaling, that regulate cell …

Deltex (Dx) is a context-dependent regulator of Notch signaling that can act in a non-
canonical fashion by facilitating the endocytosis of the Notch receptor. In an RNAi-based …