ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries
This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …
Genetic variation, brain, and intelligence differences
Individual differences in human intelligence, as assessed using cognitive test scores, have a
well-replicated, hierarchical phenotypic covariance structure. They are substantially stable …
well-replicated, hierarchical phenotypic covariance structure. They are substantially stable …
Brain imaging genomics: integrated analysis and machine learning
L Shen, PM Thompson - Proceedings of the IEEE, 2019 - ieeexplore.ieee.org
Brain imaging genomics is an emerging data science field, where integrated analysis of
brain imaging and genomics data, often combined with other biomarker, clinical, and …
brain imaging and genomics data, often combined with other biomarker, clinical, and …
Insights into clinical, genetic, and pathological aspects of hereditary spastic paraplegias: a comprehensive overview
LEO Elsayed, IZ Eltazi, AE Ahmed… - Frontiers in Molecular …, 2021 - frontiersin.org
Hereditary spastic paraplegias (HSP) are a heterogeneous group of motor
neurodegenerative disorders that have the core clinical presentation of pyramidal syndrome …
neurodegenerative disorders that have the core clinical presentation of pyramidal syndrome …
The genome-wide impact of trisomy 21 on DNA methylation and its implications for hematopoiesis
IS Muskens, S Li, T Jackson, N Elliot… - Nature …, 2021 - nature.com
Down syndrome is associated with genome-wide perturbation of gene expression, which
may be mediated by epigenetic changes. We perform an epigenome-wide association study …
may be mediated by epigenetic changes. We perform an epigenome-wide association study …
DNA methylation signatures of aggression and closely related constructs: A meta-analysis of epigenome-wide studies across the lifespan
DNA methylation profiles of aggressive behavior may capture lifetime cumulative effects of
genetic, stochastic, and environmental influences associated with aggression. Here, we …
genetic, stochastic, and environmental influences associated with aggression. Here, we …
Harnessing peripheral DNA methylation differences in the Alzheimer's Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease
A Vasanthakumar, JW Davis, K Idler, JF Waring… - Clinical …, 2020 - Springer
Background Alzheimer's disease (AD) is a chronic progressive neurodegenerative disease
impacting an estimated 44 million adults worldwide. The causal pathology of AD …
impacting an estimated 44 million adults worldwide. The causal pathology of AD …
[HTML][HTML] Epigenome-wide association study of attention-deficit/hyperactivity disorder symptoms in adults
Background Previous studies have reported associations between attention-
deficit/hyperactivity disorder symptoms and DNA methylation in children. We report the first …
deficit/hyperactivity disorder symptoms and DNA methylation in children. We report the first …
In silico identification of single nucleotide variations at CpG sites regulating CpG island existence and size
Genetic and epigenetic modifications of genes involved in the key regulatory pathways play
a significant role in the pathophysiology and progression of multifactorial diseases. The …
a significant role in the pathophysiology and progression of multifactorial diseases. The …
Integrative omics analysis reveals epigenomic and transcriptomic signatures underlying brain structural deficits in major depressive disorder
Several lines of evidence support the involvement of transcriptomic and epigenetic
mechanisms in the brain structural deficits of major depressive disorder (MDD) separately …
mechanisms in the brain structural deficits of major depressive disorder (MDD) separately …