Perineuronal nets (PNNs) are extracellular matrix (ECM) chondroitin sulfate proteoglycan
(CSPG)-containing structures that surround the soma and dendrites of various mammalian …

Regeneration is the process of replacing/restoring a damaged cell/tissue/organ to its full
function and is limited respecting complexity of specific organ structures and the level of …

Epilepsy is a neurological disorder afflicting~ 65 million people worldwide. It is caused by
aberrant synchronized firing of populations of neurons primarily due to imbalance between …

Microglia shape the synaptic environment in health and disease, but synapses do not exist
in a vacuum. Instead, pre-and postsynaptic terminals are surrounded by extracellular matrix …

Brain extracellular space is the narrow microenvironment that surrounds every cell of the
central nervous system. It contains a solution that closely resembles cerebrospinal fluid with …

Perineuronal nets (PNNs) are extracellular matrix structures mainly enwrapping
parvalbumin-expressing inhibitory neurons. The assembly of PNNs coincides with the end of …

During restricted time windows of postnatal life, called critical periods, neural circuits are
highly plastic and are shaped by environmental stimuli. In several mammalian brain areas …

The relationship between neurons and perineuronal nets (PNNs) is attracting attention as a
central mechanism controlling brain plasticity. In the cortex, PNNs primarily surround …

A structural scaffold embedding brain cells and vasculature is known as extracellular matrix
(ECM). The physical appearance of ECM in the central nervous system (CNS) ranges from a …

Long-term potentiation of excitatory synapses on pyramidal neurons in the stratum radiatum
rarely occurs in hippocampal area CA2. Here, we present evidence that perineuronal nets …