Antihypertensive drugs and brain function: mechanisms underlying therapeutically beneficial and harmful neuropsychiatric effects
C Carnovale, C Perrotta, S Baldelli… - Cardiovascular …, 2023 - academic.oup.com
A bidirectional relationship exists between hypertension and psychiatric disorders, including
unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis …
unipolar and bipolar depression, anxiety, post-traumatic stress disorder (PTSD), psychosis …
[HTML][HTML] The GABA polarity shift and bumetanide treatment: making sense requires unbiased and undogmatic analysis
Y Ben-Ari, E Cherubini - Cells, 2022 - mdpi.com
GABA depolarizes and often excites immature neurons in all animal species and brain
structures investigated due to a developmentally regulated reduction in intracellular chloride …
structures investigated due to a developmentally regulated reduction in intracellular chloride …
Inhibition mechanism of NKCC1 involves the carboxyl terminus and long-range conformational coupling
The Na-K-2Cl cotransporter-1 (NKCC1) is an electroneutral Na+-dependent transporter
responsible for simultaneously translocating Na+, K+, and Cl− ions into cells. In human …
responsible for simultaneously translocating Na+, K+, and Cl− ions into cells. In human …
Bumetanide oral solution for the treatment of children and adolescents with autism spectrum disorder: Results from two randomized phase III studies
J Fuentes, M Parellada, C Georgoula… - Autism …, 2023 - Wiley Online Library
The efficacy and safety of bumetanide oral solution for the treatment of autism spectrum
disorder (ASD) in children and adolescents was evaluated in two international, multi‐center …
disorder (ASD) in children and adolescents was evaluated in two international, multi‐center …
[HTML][HTML] The domestic chick as an animal model of autism spectrum disorder: building adaptive social perceptions through prenatally formed predispositions
T Matsushima, T Izumi, G Vallortigara - Frontiers in Neuroscience, 2024 - frontiersin.org
Equipped with an early social predisposition immediately post-birth, humans typically form
associations with mothers and other family members through exposure learning, canalized …
associations with mothers and other family members through exposure learning, canalized …
Delaying the GABA shift indirectly affects membrane properties in the developing hippocampus
C Peerboom, S de Kater, N Jonker… - Journal of …, 2023 - Soc Neuroscience
During the first two postnatal weeks, intraneuronal chloride concentrations in rodents
gradually decrease, causing a shift from depolarizing to hyperpolarizing GABA responses …
gradually decrease, causing a shift from depolarizing to hyperpolarizing GABA responses …
[HTML][HTML] A bibliometrics analysis and visualization of autism spectrum disorder
P Rong, Q Fu, X Zhang, H Liu, S Zhao, X Song… - Frontiers in …, 2022 - frontiersin.org
Background The prevalence of autism spectrum disorder (ASD) increased rapidly in the last
20 years. Although related research has developed rapidly, little is known about its etiology …
20 years. Although related research has developed rapidly, little is known about its etiology …
Can bumetanide be a miraculous medicine for autism spectrum disorder: Meta-analysis evidence from randomized controlled trials
HL Xiao, H Zhu, JQ Jing, SJ Jia, SH Yu… - Research in Autism …, 2024 - Elsevier
Background The efficacy of bumetanide on autism spectrum disorders (ASD) has been
extensively studied, but the results remain inconclusive, necessitating a critical examination …
extensively studied, but the results remain inconclusive, necessitating a critical examination …
Intranasal Oxytocin for Patients With Autism Spectrum Disorder: A Comprehensive Meta-Analysis of Preclinical and Clinical Studies
The neuropeptide oxytocin (OXT) has been identified as a potential therapeutic intervention
for ASD due to its involvement in social bonding and affiliative behaviors. The present study …
for ASD due to its involvement in social bonding and affiliative behaviors. The present study …
[HTML][HTML] A wholistic view of how bumetanide attenuates autism spectrum disorders
The specific NKCC1 cotransporter antagonist, bumetanide, attenuates the severity of Autism
Spectrum Disorders (ASD), and many neurodevelopmental or neurodegenerative disorders …
Spectrum Disorders (ASD), and many neurodevelopmental or neurodegenerative disorders …