Background The diminished glucose lowering effect of insulin in obesity, called “insulin
resistance,” is associated with glucose intolerance, type 2 diabetes, and other serious …

Colorectal cancer is considered one of the major malignancies that threaten the lives and
health of people around the world. Patients with CRC are prone to post-operative local …

Adipose tissues display a remarkable ability to adapt to the dietary status. Here, we have
applied single-nucleus RNA-seq to map the plasticity of mouse epididymal white adipose …

Abstract Purpose of Review Omics-based technologies were suggested to provide an
advanced understanding of obesity etiology and its metabolic consequences. This review …

Colorectal cancer (CRC) is one of the most common human malignancies worldwide. Along
with apoptosis and inflammation, autophagy is one of three important mechanisms in CRC …

G protein-coupled receptors (GPCRs) are a large family of cell surface receptors that are the
targets for many different classes of pharmacotherapy. The islets of Langerhans are central …

CD39 (nucleoside triphosphate diphosphohydrolase) and Ecto-5-nucleotidase (CD73) have
been recognized as important factors mediating various pathological and physiological …

Background Obesity is characterized by increased adipose tissue mass that results from
increased fat cell size (hypertrophy) and number (hyperplasia). The molecular mechanisms …

Obesity, and the obesity-associated inflammation, represents a major risk factor for the
development of chronic diseases, including colorectal cancer (CRC). Dysfunctional visceral …

Colorectal cancer (CRC) is among the major threatening diseases worldwide, being the
third most common cancer, and a leading cause of death, with a global incidence expected …