Alcohol use disorders (AUDs) are complex traits, meaning that variations in many genes
contribute to the risk, as does the environment. Although the total genetic contribution to risk …

Alcohol consumption is common across subpopulations in the United States. However, the
health burden associated with alcohol consumption varies across groups, including those …

Abstract The Trans-Omics for Precision Medicine (TOPMed) programme seeks to elucidate
the genetic architecture and biology of heart, lung, blood and sleep disorders, with the …

Abstract Approximately 3.6% of cancers worldwide derive from chronic alcohol drinking,
including those of the upper aerodigestive tract, the liver, the colorectum and the breast …

A causal association has been established between alcohol consumption and cancers of
the oral cavity, pharynx, larynx, oesophagus, liver, colon, rectum, and, in women, breast; an …

The primary enzymes involved in alcohol metabolism are alcohol dehydrogenase (ADH)
and aldehyde dehydrogenase (ALDH). Both enzymes occur in several forms that are …

In this article, we reviewed the association between alcohol drinking and head and neck
cancer (HNC) and its subsites, using the available literature. Alcohol drinking is an …

Context Alcohol dependence is a serious and common public health problem. It is well
established that genetic factors play a major role in the development of this disorder …

Background: Phenylthiocarbamide (PTC) and 6‐n‐propylthiouracil (PROP), chemically
related compounds, are probes for genetic variation in bitter taste, although PROP is safer …

Variants of three genes encoding alcohol-metabolizing enzymes, the aldehyde
dehydrogenase gene ALDH2 and the alcohol dehydrogenase genes ADH1B and ADH1C …