[HTML][HTML] A comprehensive review of artificial intelligence and network based approaches to drug repurposing in Covid-19
Conventional drug discovery and development is tedious and time-taking process; because
of which it has failed to keep the required pace to mitigate threats and cater demands of viral …
of which it has failed to keep the required pace to mitigate threats and cater demands of viral …
[HTML][HTML] ACE2 Shedding and the Role in COVID-19
J Wang, H Zhao, Y An - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Angiotensin converting enzyme 2 (ACE2), a transmembrane glycoprotein, is an important
part of the renin-angiotensin system (RAS). In the COVID-19 epidemic, it was found to be the …
part of the renin-angiotensin system (RAS). In the COVID-19 epidemic, it was found to be the …
[HTML][HTML] Circulating ACE2 activity predicts mortality and disease severity in hospitalized COVID-19 patients
M Fagyas, Z Fejes, R Sütő, Z Nagy, B Székely… - International Journal of …, 2022 - Elsevier
Objectives Angiotensin-converting enzyme 2 (ACE2) represents the primary receptor for
SARS-CoV-2 to enter endothelial cells. Here we investigated circulating ACE2 activity to …
SARS-CoV-2 to enter endothelial cells. Here we investigated circulating ACE2 activity to …
Alveolar, endothelial, and organ injury marker dynamics in severe COVID-19
DE Leisman, A Mehta, BT Thompson… - American Journal of …, 2022 - atsjournals.org
Rationale: Alveolar and endothelial injury may be differentially associated with coronavirus
disease (COVID-19) severity over time. Objectives: To describe alveolar and endothelial …
disease (COVID-19) severity over time. Objectives: To describe alveolar and endothelial …
An ACE2 decoy can be administered by inhalation and potently targets omicron variants of SARS‐CoV‐2
L Zhang, KK Narayanan, L Cooper… - EMBO Molecular …, 2022 - embopress.org
Monoclonal antibodies targeting the SARS‐CoV‐2 spike (S) neutralize infection and are
efficacious for the treatment of COVID‐19. However, SARS‐CoV‐2 variants, notably …
efficacious for the treatment of COVID‐19. However, SARS‐CoV‐2 variants, notably …
Thyroid disease and hypothyroidism are associated with poor COVID-19 outcomes: A systematic review, meta-analysis, and meta-regression
Background and aims Coronavirus disease (COVID-19) still becomes a global burden that
affected people in different groups. The aim of this study was to evaluate the association …
affected people in different groups. The aim of this study was to evaluate the association …
Low vitamin D levels predict outcomes of COVID-19 in patients with both severe and non-severe disease at hospitalization
Purpose Low vitamin D in COVID-19 have been related to worse outcomes. However, most
of the studies conducted so far were not-controlled and retrospective, including biases …
of the studies conducted so far were not-controlled and retrospective, including biases …
Sex-and age-specific regulation of ACE2: Insights into severe COVID-19 susceptibility
Aged males disproportionately succumb to increased COVID-19 severity, hospitalization,
and mortality compared to females. Angiotensin-converting enzyme 2 (ACE2) and …
and mortality compared to females. Angiotensin-converting enzyme 2 (ACE2) and …
[HTML][HTML] Point-specific interactions of isovitexin with the neighboring amino acid residues of the hACE2 receptor as a targeted therapeutic agent in suppressing the …
Objective: Despite the development of several vaccines against severe acute respiratory
syndrome coronavirus-2, the need for an additional prophylactic agent is evident. In recent …
syndrome coronavirus-2, the need for an additional prophylactic agent is evident. In recent …
[PDF][PDF] Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity
A recent paper in Cell entitled ''Soluble ACE2-mediated cell entry of SARS-CoV-2 via
interaction with proteins related to the renin-angiotensin system''by Yeung et al.(2021) …
interaction with proteins related to the renin-angiotensin system''by Yeung et al.(2021) …