Human ACE2 expression, a major tropism determinant for SARS-CoV-2, is regulated by upstream and intragenic elements
JN Snouwaert, LA Jania, T Nguyen, DR Martinez… - PLoS …, 2023 - journals.plos.org
Angiotensin-converting enzyme 2 (ACE2), part of the renin-angiotensin system (RAS),
serves as an entry point for SARS-CoV-2, leading to viral proliferation in permissive cell …
serves as an entry point for SARS-CoV-2, leading to viral proliferation in permissive cell …
Alternative renin-angiotensin system
M Bader, UM Steckelings, N Alenina, RAS Santos… - …, 2024 - Am Heart Assoc
The renin-angiotensin system is the most important peptide hormone system in the
regulation of cardiovascular homeostasis. Its classical arm consists of the enzymes, renin …
regulation of cardiovascular homeostasis. Its classical arm consists of the enzymes, renin …
Evidence in favor of the essentiality of human cell membrane-bound ACE2 and against soluble ACE2 for SARS-CoV-2 infectivity
A recent paper in Cell entitled ''Soluble ACE2-mediated cell entry of SARS-CoV-2 via
interaction with proteins related to the renin-angiotensin system''by Yeung et al.(2021) …
interaction with proteins related to the renin-angiotensin system''by Yeung et al.(2021) …
The systemic renin-angiotensin system in COVID-19
R Reindl-Schwaighofer, S Hödlmoser, O Domenig… - Scientific Reports, 2022 - nature.com
SARS-CoV-2 gains cell entry via angiotensin-converting enzyme (ACE) 2, a membrane-
bound enzyme of the “alternative”(alt) renin-angiotensin system (RAS). ACE2 counteracts …
bound enzyme of the “alternative”(alt) renin-angiotensin system (RAS). ACE2 counteracts …
Potential COVID‐19 therapeutic approaches targeting angiotensin‐converting enzyme 2; an updated review
COVID‐19 has spread swiftly throughout the world posing a global health emergency. The
significant numbers of deaths attributed to this pandemic have researchers battling to …
significant numbers of deaths attributed to this pandemic have researchers battling to …
HMGB1, NLRP3, IL-6 and ACE2 levels are elevated in COVID-19 with headache: a window to the infection-related headache mechanism
Background and aim Pathogenesis of COVID-19-related headache is unknown, though the
induction of the trigeminal neurons through inflammation is proposed. We aimed to …
induction of the trigeminal neurons through inflammation is proposed. We aimed to …
COVID-19 Vasculitis and vasculopathy-Distinct immunopathology emerging from the close juxtaposition of Type II Pneumocytes and Pulmonary Endothelial Cells
Abstract The SARS-CoV-2 virus ACE-2 receptor utilization for cellular entry and the defined
ACE-2 receptor role in cardiovascular medicine hinted at dysregulated endothelial function …
ACE-2 receptor role in cardiovascular medicine hinted at dysregulated endothelial function …
Severity of coronavirus disease 19: Profile of inflammatory markers and ACE (rs4646994) and ACE2 (rs2285666) gene polymorphisms in Iraqi patients
ZS Mahmood, HY Fadhil, TAA Hussein, AH Ad'hiah - Meta gene, 2022 - Elsevier
Susceptibility to coronavirus disease 2019 (COVID-19) and disease severity has recently
been associated with inflammatory markers and genetic polymorphisms of ACE (angiotensin …
been associated with inflammatory markers and genetic polymorphisms of ACE (angiotensin …
Quantifying renin-angiotensin-system alterations in COVID-19
The renin-angiotensin system (RAS) plays a pivotal role in a wide series of physiological
processes, among which inflammation and blood pressure regulation. One of its key …
processes, among which inflammation and blood pressure regulation. One of its key …
S protein, ACE2 and host cell proteases in SARS-CoV-2 cell entry and infectivity; is soluble ACE2 a two blade sword? A narrative review
R Nejat, MF Torshizi, DJ Najafi - Vaccines, 2023 - mdpi.com
Since the spread of the deadly virus SARS-CoV-2 in late 2019, researchers have restlessly
sought to unravel how the virus enters the host cells. Some proteins on each side of the …
sought to unravel how the virus enters the host cells. Some proteins on each side of the …