COVID-19 and one-carbon metabolism

J Perła-Kaján, H Jakubowski - International journal of molecular sciences, 2022 - mdpi.com
Dysregulation of one-carbon metabolism affects a wide range of biological processes and is
associated with a number of diseases, including cardiovascular disease, dementia, neural …

Early shedding of membrane-bounded ACE2 could be an indicator for disease severity in SARS-CoV-2

V Mariappan, P Ranganadin, L Shanmugam, SR Rao… - Biochimie, 2022 - Elsevier
SARS-CoV-2 uses membrane bound Angiotensin-Converting Enzyme 2 (ACE2) as a key
host receptor for its entry. However, inconsistent results are available in terms of shedding of …

An overview of adipose tissue ACE2 modulation by diet and obesity. Potential implications in COVID-19 infection and severity

S Gomez-Zorita, I Milton-Laskibar… - International Journal of …, 2021 - mdpi.com
The present review is aimed at analysing the current evidence concerning the potential
modulation of obesity and/or diet in adipose tissue ACE2. Additionally, the potential …

Tryptophan metabolism and COVID-19-induced skeletal muscle damage: Is ACE2 a key regulator?

H Takeshita, K Yamamoto - Frontiers in nutrition, 2022 - frontiersin.org
The severity of coronavirus disease 2019 (COVID-19) is characterized by systemic damage
to organs, including skeletal muscle, due to excessive secretion of inflammatory cytokines …

The prognostic importance of the angiotensin II/angiotensin-(1–7) ratio in patients with SARS-CoV-2 infection

LM Amezcua-Guerra, L Del Valle… - Therapeutic …, 2022 - journals.sagepub.com
Background: Information about angiotensin II (Ang II), angiotensin-converting enzyme 2
(ACE2), and Ang-(1–7) levels in patients with COVID-19 is scarce. Objective: To …

Molecular mechanisms of endothelialitis in SARS-CoV-2 infection: Evidence for VE-cadherin cleavage by ACE2

L Bouillet, A Deroux, M Benmarce, C Guérin… - International Journal of …, 2023 - mdpi.com
Long COVID-19 syndrome appears after Severe Acute Respiratory Syndrome-Corona Virus
(SARS-CoV-2) infection with acute damage to microcapillaries, microthrombi, and …

SARS-CoV-2 infection modulates ACE2 function and subsequent inflammatory responses in swabs and plasma of COVID-19 patients

L Gutierrez-Chamorro, E Riveira-Munoz, C Barrios… - Viruses, 2021 - mdpi.com
Angiotensin converting enzyme 2 (ACE2) is a host ectopeptidase and the receptor for the
SARS-CoV-2 virus, albeit virus-ACE2 interaction goes far beyond viral entry into target cells …

Impact of ACE2 on the susceptibility and vulnerability to COVID-19

KG Pringle, LK Philp - Journal of Endocrinology, 2023 - joe.bioscientifica.com
Angiotensin-converting enzyme 2 (ACE2) is not only the viral receptor for the novel
coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) but is also …

Upregulated miR-200c is associated with downregulation of the functional receptor for severe acute respiratory syndrome coronavirus 2 ACE2 in individuals with …

J Bellae Papannarao, DO Schwenke… - International Journal of …, 2022 - nature.com
Obesity is a risk factor for coronavirus disease 2019 (COVID-19) infection, with studies
demonstrating the prevalence of individuals with obesity admitted with COVID-19 ranging …

[HTML][HTML] Epigenetic mechanisms and host factors impact ACE2 gene expression: Implications in COVID-19 susceptibility

G Daniel, AR Paola, G Nancy, SO Fernando… - Infection, Genetics and …, 2022 - Elsevier
Background The ACE2 protein acts as a gateway for SARS-CoV-2 in the host cell, playing
an essential role in susceptibility to infection by this virus. Genetics and epigenetic …