Microbial translocation and microbiome dysbiosis in HIV-associated immune activation

AS Zevin, L McKinnon, A Burgener… - Current Opinion in HIV …, 2016 - journals.lww.com
Microbial translocation and microbiome dysbiosis in HIV-asso... : Current Opinion in HIV and
AIDS Microbial translocation and microbiome dysbiosis in HIV-associated immune activation …

[HTML][HTML] Th17 CD4+ T-cell as a preferential target for HIV reservoirs

C Renault, N Veyrenche, F Mennechet… - Frontiers in …, 2022 - frontiersin.org
Among CD4+ T-cells, T helper 17 (Th17) cells play a sentinel role in the defense against
bacterial/fungal pathogens at mucosal barriers. However, Th17 cells are also highly …

[HTML][HTML] Increased levels of inflammatory cytokines in the female reproductive tract are associated with altered expression of proteases, mucosal barrier proteins, and …

KB Arnold, A Burgener, K Birse, L Romas… - Mucosal …, 2016 - Elsevier
Elevated inflammatory cytokines (EMCs) at mucosal surfaces have been associated with
HIV susceptibility, but the underlying mechanisms remain unclear. We characterized the …

[HTML][HTML] HIV persists in CCR6+ CD4+ T cells from colon and blood during antiretroviral therapy

A Gosselin, TRW Salinas, D Planas, VS Wacleche… - Aids, 2017 - journals.lww.com
Objectives: The objective of this article is to investigate the contribution of colon and blood
CD4+ T-cell subsets expressing the chemokine receptor CCR6 to HIV persistence during …

The relationship between sex hormones, the vaginal microbiome and immunity in HIV-1 susceptibility in women

JM Wessels, AM Felker, HA Dupont… - Disease models & …, 2018 - journals.biologists.com
The role of sex hormones in regulating immune responses in the female genital tract has
been recognized for decades. More recently, it has become increasingly clear that sex …

HIV and mucosal barrier interactions: consequences for transmission and pathogenesis

A Burgener, I McGowan, NR Klatt - Current opinion in immunology, 2015 - Elsevier
Highlights•Mucosal barrier dysfunction is a key component of HIV transmission and
pathogenesis.•Inflammation results in mucosal damage, target cell accumulation, and …

[HTML][HTML] The double game played by Th17 cells in infection: host defense and immunopathology

M Paroli, R Caccavale, MT Fiorillo, L Spadea… - Pathogens, 2022 - mdpi.com
T-helper 17 (Th17) cells represent a subpopulation of CD4+ T lymphocytes that play an
essential role in defense against pathogens. Th17 cells are distinguished from Th1 and Th2 …

The genital tract and rectal microbiomes: their role in HIV susceptibility and prevention in women

SSA Karim, C Baxter, JAS Passmore… - African Journal of …, 2019 - journals.lww.com
Introduction: Young women in sub-Saharan Africa are disproportionately affected by HIV,
accounting for 25% of all new infections in 2017. Several behavioural and biological factors …

[HTML][HTML] Beyond bacterial vaginosis: vaginal lactobacilli and HIV risk

E Armstrong, R Kaul - Microbiome, 2021 - Springer
HIV incidence continues to be unacceptably high in Eastern and Southern Africa, with
women disproportionately affected. An increased per-contact risk of HIV acquisition among …

Impact of standard bacterial vaginosis treatment on the genital microbiota, immune milieu, and ex vivo human immunodeficiency virus susceptibility

V Joag, O Obila, P Gajer, MC Scott… - Clinical Infectious …, 2019 - academic.oup.com
Background Genital immunology is a key determinant of human immunodeficiency virus
(HIV) susceptibility. Both factors are modulated by bacterial vaginosis (BV) and, to some …