The endothelins comprise three structurally similar 21-amino acid peptides. Endothelin-1
and-2 activate two G-protein coupled receptors, ETA and ETB, with equal affinity, whereas …

Experimental work during the past 15 years has demonstrated that endothelial cells in the
heart play an obligatory role in regulating and maintaining cardiac function, in particular, at …

Endothelin (ET) peptides and their receptors are intimately involved in the physiological
control of systemic blood pressure and body Na homeostasis, exerting these effects through …

Outer membrane vesicles (OMVs) are nanosized proteoliposomes derived from the outer
membrane of Gram-negative bacteria. They are ubiquitously produced both in culture and …

Apelin receptors, present on vascular smooth muscle cells, endothelium, and
cardiomyocytes, are activated by the family of apelin peptides to elicit cardiovascular effects …

The family of apelin peptides is derived from a single gene and activates the 7-
transmembrane G-protein-coupled receptor (GPCR) APJ. Apelins have been shown to be …

Nitric oxide (NO) and endothelin-1 (ET-1) are natural counterparts in vascular function, and it
is becoming increasingly clear that an imbalance between these two mediators is a …

We recently demonstrated that human melanocyte proliferation and differentiation could be
stimulated by endothelin (ET) derivatives via a receptor-mediated signal transduction …

First published in 1990: The Endothelium: Modulator of Cardiovascular Function takes a
comprehensive look at the role of the endothelium in cardiovascular control in health and …

The present study examined the effects of endothelin-1 on phosphoinositide hydrolysis,
diacylglycerol formation, and the induction of myocardial cell hypertrophy utilizing a well …