Transcription factor EB (TFEB) is considered the master transcriptional regulator of
autophagy and lysosomal biogenesis, which regulates target gene expression through …

Background Diabetes mellitus (DM) is an endocrine and metabolic disease caused by a
variety of pathogenic factors, including genetic factors, environmental factors and behavior …

Objective To date, the only enzyme known to be responsible for the hydrolysis of cholesteryl
esters and triacylglycerols in the lysosome at acidic pH is lysosomal acid lipase (LAL). Lipid …

Dysregulated bile acid (BA)/lipid metabolism and gut bacteria dysbiosis are tightly
associated with the development of obesity and non-alcoholic fatty liver disease (NAFLD) …

Although survival from breast cancer has dramatically increased, many will develop
recurrent, metastatic disease. Unfortunately, survival for this stage of disease remains very …

Macroautophagic/autophagic degradation of lipid droplets, lipophagy, is activated by fasting
but repressed by feeding. Surprisingly, our recent study showed that this is not the case in …

Background Non-fasting lipid assessment can help predict cardiovascular disease risks and
is linked to multiple diseases, particularly diabetes. The significance of non-fasting lipid …

Immune checkpoint blockade (ICB) has revolutionized cancer therapy but has had limited
utility in several solid tumors such as breast cancer, a major cause of cancer-related …

Scavenger receptor class B, member 2 (SCARB2) is linked to Gaucher disease (GD) and
Parkinson's disease (PD). Deficiency in the SCARB2 gene causes progressive myoclonus …

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