Lipoprotein (a) in atherosclerotic cardiovascular disease and aortic stenosis: a European Atherosclerosis Society consensus statement

F Kronenberg, S Mora, ESG Stroes… - European heart …, 2022 - academic.oup.com
Abstract This 2022 European Atherosclerosis Society lipoprotein (a)[Lp (a)] consensus
statement updates evidence for the role of Lp (a) in atherosclerotic cardiovascular disease …

Lipid and lipoprotein metabolism

KR Feingold - Endocrinology and Metabolism Clinics, 2022 - endo.theclinics.com
Lipids are insoluble in water and therefore cholesterol and triglycerides need to be
transported in association with proteins (ie, lipoproteins) in the bloodstream. Lipoproteins …

[HTML][HTML] Lipoprotein (a) beyond the kringle IV repeat polymorphism: the complexity of genetic variation in the LPA gene

S Coassin, F Kronenberg - Atherosclerosis, 2022 - Elsevier
Abstract High lipoprotein (a)[Lp (a)] concentrations are one of the most important genetically
determined risk factors for cardiovascular disease. Lp (a) concentrations are an enigmatic …

Protein-coding repeat polymorphisms strongly shape diverse human phenotypes

RE Mukamel, RE Handsaker, MA Sherman, AR Barton… - Science, 2021 - science.org
Many human proteins contain domains that vary in size or copy number because of variable
numbers of tandem repeats (VNTRs) in protein-coding exons. However, the relationships of …

[HTML][HTML] Frequent questions and responses on the 2022 lipoprotein (a) consensus statement of the European Atherosclerosis Society

F Kronenberg, S Mora, ESG Stroes, BA Ference… - Atherosclerosis, 2023 - Elsevier
Abstract In 2022, the European Atherosclerosis Society (EAS) published a new consensus
statement on lipoprotein (a)[Lp (a)], summarizing current knowledge about its causal …

[HTML][HTML] Daring to dream: Targeting lipoprotein (a) as a causal and risk-enhancing factor

ML Koschinsky, ESG Stroes, F Kronenberg - Pharmacological Research, 2023 - Elsevier
Abstract Lipoprotein (a)[Lp (a)], a distinct lipoprotein class, has become a major focus for
cardiovascular research. This review is written in light of the recent guideline and consensus …

Lipoprotein (a) in clinical practice: A guide for the clinician

C Krittanawong, NS Maitra, AH El-Sherbini… - Progress in …, 2023 - Elsevier
Cardiovascular disease (CVD) remains the leading cause of death worldwide. Serum
lipoprotein (a)(Lp (a)) has been shown to be an independent and causative risk factor for …

[HTML][HTML] Comparison of multiple imputation algorithms and verification using whole-genome sequencing in the CMUH genetic biobank

TY Liu, CF Lin, HT Wu, YL Wu, YC Chen, CC Liao… - Biomedicine, 2021 - ncbi.nlm.nih.gov
A genome-wide association study (GWAS) can be conducted to systematically analyze the
contributions of genetic factors to a wide variety of complex diseases. Nevertheless, existing …

Lipoprotein (a) and cardiovascular disease: a missing link for premature atherosclerotic heart disease and/or residual risk

H Melita, AA Manolis, TA Manolis… - Journal of …, 2022 - journals.lww.com
Lipoprotein (a) or lipoprotein “little a”[Lp (a)] is an under-recognized causal risk factor for
cardiovascular (CV) disease (CVD), including coronary atherosclerosis, aortic valvular …

Familial hypercholesterolemia and elevated lipoprotein (a): cascade testing and other implications for contextual models of care

WJ Loh, DC Chan, P Mata, GF Watts - Frontiers in Genetics, 2022 - frontiersin.org
Elevated lipoprotein (a)[Lp (a)], a predominantly genetic disorder, is a causal risk factor for
atherosclerotic cardiovascular disease (ASCVD) and calcific aortic valvular disease …