Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis

S Murao, H Nakata, I Roberts, K Yamakawa - Critical Care, 2021 - Springer
Background Tranexamic acid (TXA) reduces surgical bleeding and reduces death from
bleeding after trauma and childbirth. However, its effects on thrombotic events and seizures …

Fibrinolysis shutdown in trauma: historical review and clinical implications

HB Moore, EE Moore, MD Neal… - Anesthesia & …, 2019 - journals.lww.com
Despite over a half-century of recognizing fibrinolytic abnormalities after trauma, we remain
in our infancy in understanding the underlying mechanisms causing these changes …

Early prehospital tranexamic acid following injury is associated with a 30-day survival benefit: a secondary analysis of a randomized clinical trial

SR Li, F Guyette, J Brown, M Zenati, KM Reitz… - Annals of …, 2021 - journals.lww.com
Objective: We sought to characterize the timing of administration of prehospital tranexamic
acid (TXA) and associated outcome benefits. Background: TXA has been shown to be safe …

[HTML][HTML] Use of tranexamic acid in major trauma: a sex-disaggregated analysis of the Clinical Randomisation of an Antifibrinolytic in Significant Haemorrhage (CRASH …

T Nutbeam, I Roberts, L Weekes, H Shakur-Still… - British Journal of …, 2022 - Elsevier
Background Women are less likely than men to receive some emergency treatments. This
study examines whether the effect of tranexamic acid (TXA) on mortality in trauma patients …

Topical tranexamic acid compared with anterior nasal packing for treatment of epistaxis in patients taking antiplatelet drugs: randomized controlled trial

R Zahed, MH Mousavi Jazayeri… - Academic …, 2018 - Wiley Online Library
Objective We evaluated the efficacy of topical application of the injectable form of tranexamic
acid (TXA) compared with anterior nasal packing (ANP) for the treatment of epistaxis in …

Increased risk of fibrinolysis shutdown among severely injured trauma patients receiving tranexamic acid

JP Meizoso, R Dudaryk, MB Mulder… - Journal of Trauma …, 2018 - journals.lww.com
BACKGROUND The association between tranexamic acid (TXA) and fibrinolysis shutdown
is unknown. We hypothesize that TXA is associated with fibrinolysis shutdown in critically …

Optimisation of the dosage of tranexamic acid in trauma patients with population pharmacokinetic analysis

S Grassin‐Delyle, OM Theusinger, R Albrecht… - …, 2018 - Wiley Online Library
Tranexamic acid is used both pre‐hospital and in‐hospital as an antifibrinolytic drug to treat
or prevent hyperfibrinolysis in trauma patients; dosing, however, remains empirical. We …

Prehospital tranexamic acid is associated with a dose-dependent decrease in syndecan-1 after trauma: A secondary analysis of a prospective randomized trial

DS Gruen, JB Brown, FX Guyette… - Journal of Trauma …, 2023 - journals.lww.com
BACKGROUND In the Study of Tranexamic Acid During Air and Ground Prehospital
Transport (STAAMP) Trial, prehospital tranexamic acid (TXA) was associated with lower …

Tranexamic acid in neurosurgery: a controversy indication

JL de Faria, J da Silva Brito, LT Costa e Silva… - Neurosurgical …, 2021 - Springer
Tranexamic acid (TXA) is one of the measures indicated to reduce bleeding and the need for
volume replacement. However, data on risks and benefits are controversial. This study …

Benefits of the tranexamic acid in head trauma with no extracranial bleeding: a prospective follow-up of 180 patients

O Chakroun-Walha, A Samet, M Jerbi, A Nasri… - European Journal of …, 2019 - Springer
Introduction Tranexamic acid (TXA) is one of the debated therapies in the management of
traumatic brain injury (TBI). We conducted this study to evaluate the benefits of TXA in TBI on …