[HTML][HTML] Pathogenetic analysis of polycystic ovary syndrome from the perspective of omics

CZ Pei, L Jin, KH Baek - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Polycystic ovary syndrome (PCOS) is the most common gynecological endocrine disease,
involving multiple genes, multiple pathways, and complex hormone secretion processes …

Circular RNAs: emerging modulators in the pathophysiology of polycystic ovary syndrome and their clinical implications

S Mazloomi, V Mousavi… - Current Molecular …, 2024 - ingentaconnect.com
Polycystic ovary syndrome (PCOS) is a prevalent endocrine/metabolic disorder in women of
reproductive age. PCOS is characterized by hyperandrogenism, polycystic ovary …

An improved dehydroepiandrosterone-induced rat model of polycystic ovary syndrome (PCOS): Post-pubertal improve PCOS's features

EJ Kim, M Jang, JH Choi, KS Park… - Frontiers in endocrinology, 2018 - frontiersin.org
Complete animal models investigating the pathogenesis and treatment of polycystic ovarian
syndrome (PCOS) are not completely established. Although dehydroepiandrosterone …

A polygenic and phenotypic risk prediction for polycystic ovary syndrome evaluated by phenome-wide association studies

YY Joo, KE Actkins, JA Pacheco… - The Journal of …, 2020 - academic.oup.com
Context As many as 75% of patients with polycystic ovary syndrome (PCOS) are estimated
to be unidentified in clinical practice. Objective Utilizing polygenic risk prediction, we aim to …

Regulated nuclear accumulation of a histone methyltransferase times the onset of heterochromatin formation in C. elegans embryos

B Mutlu, HM Chen, JJ Moresco, BD Orelo, B Yang… - Science …, 2018 - science.org
Heterochromatin formation during early embryogenesis is timed precisely, but how this
process is regulated remains elusive. We report the discovery of a histone methyltransferase …

Multiple factors related to the secretion of glucagon‐like peptide‐1

XC Wang, H Liu, J Chen, Y Li… - International journal of …, 2015 - Wiley Online Library
The glucagon‐like peptide‐1 is secreted by intestinal L cells in response to nutrient
ingestion. It regulates the secretion and sensitivity of insulin while suppressing glucagon …

Multiomics analysis–based biomarkers in diagnosis of polycystic ovary syndrome

S Rani, P Chandna - Reproductive Sciences, 2023 - Springer
Polycystic ovarian syndrome is an utmost communal endocrine, psychological, reproductive,
and metabolic disorder that occurs in women of reproductive age with extensive range of …

Deregulation of WNT2/FZD3/β-catenin pathway compromises the estrogen synthesis in cumulus cells from patients with polycystic ovary syndrome

G Qiao, B Dong, C Zhu, C Yan, B Chen - Biochemical and Biophysical …, 2017 - Elsevier
Mechanistic insight into estrogen deficiency by polycystic ovary syndrome (PCOS) remains a
longstanding challenge in reproductive medicine. Recent advance suggest that Wingless …

The peripheral blood transcriptome identifies dysregulation of inflammatory response genes in polycystic ovary syndrome

NJ Su, J Ma, DF Feng, S Zhou, ZT Li… - Gynecological …, 2018 - Taylor & Francis
Polycystic ovary syndrome (PCOS) is a common endocrine disorder in women, resulting in
ovulation failure and other metabolic problems. However, the underlying mechanisms of it …

Molecular determination of progesterone receptor's PROGINS allele (Alu insertion) and its association with the predisposition and susceptibility to polycystic ovary …

R Mir, MA Altayar, A Hamadi, FJ Tayeb, NH Saeedi… - Mammalian …, 2022 - Springer
Polycystic ovary syndrome, previously known as Stein–Leventhal syndrome, is associated
with altered reproductive endocrinology, predisposing a young woman towards the risk of …