In diarthrodial joints, the articular cartilage, calcified cartilage, and subchondral cortical and
trabecular bone form a biocomposite—referred to as the osteochondral unit—that is …

Post-traumatic osteoarthritis (PTOA) develops after joint injury. Specifically, patients with
anterior cruciate ligament (ACL) injury have a high risk of developing PTOA. In this review …

Osteoarthritis (OA) is one of the most commonly occurring forms of arthritis in the world
today. It is a debilitating chronic illness causing pain and immense discomfort to the affected …

Injury to the joint provokes a number of local pathophysiological changes, including
synthesis of inflammatory cytokines, death of chondrocytes, breakdown of the extra‐cellular …

Background The infrapatellar fat pad (IFP) is the largest adipose deposit in the knee;
however, its contributions to the homeostasis of this organ remain undefined. To determine …

There is currently no effective medical treatment for temporomandibular joint osteoarthritis
(TMJ-OA) due to a limited understanding of its pathogenesis. This study was undertaken to …

Among patients with knee osteoarthritis (OA), postmenopausal women are over-
represented. The purpose of this study was to determine whether deficiency of female sex …

Joint injury is the predominant risk factor for post‐traumatic osteoarthritis development
(PTOA). Several non‐invasive mouse models mimicking human PTOA investigate molecular …

Background: Meniscal root tears cause menisci and their insertions to inadequately
distribute loads and potentially leave underlying articular cartilage unprotected. Untreated …

Osteoarthritis (OA) is an age-related joint disease and one of the most common
degenerative bone diseases among elderly people. The currently used therapeutic …