Oxysterols are oxidized derivatives of cholesterol produced by enzymatic activity or non-
enzymatic pathways (auto-oxidation). The oxidation processes lead to the synthesis of about …

Abstract Cytochrome 450 (CYP450) designates a group of enzymes abundant in smooth
endoplasmic reticulum of hepatocytes and epithelial cells of small intestines. The main …

The inter-individual differences in cancer susceptibility are somehow correlated with the
genetic differences that are caused by the polymorphisms. These genetic variations in drug …

Cytochrome P450 (CYP450) enzymes are the most important metabolizing enzyme family
exists among all organs. Apart from their role in the deactivation of most endogenous …

Consensus strategy was proved to be highly efficient in the recognition of gene-disease
association. Therefore, the main objective of this study was to apply theoretical approaches …

To date, no targeted therapies are available to treat triple negative breast cancer (TNBC),
while other breast cancer subtypes are responsive to current therapeutic treatment …

Vitamin D has received considerable optimistic attention as a potentially important factor in
many pathological states over the past few decades. However, the proportion of the active …

Objective The activities of four cytochrome P3A (CYP3A) subfamily members (CYP3A4,
CYP3A5, CYP3A7, and CYP3A43) are well documented in drug metabolism. However, the …

7α, 25-dihydroxycholesterol (7α, 25-DHC) is an oxysterol synthesized from 25-
hydroxycholesterol by cytochrome P450 family 7 subfamily B member 1 (CYP7B1) and is a …

Phytochemicals are a diverse group of compounds found in a variety of fruits, vegetables
and herbs, and have been reported to possess a number of health benefits. Marketed as …