Effect of posttranslational modifications and subclass on IgG activity: from immunity to immunotherapy
Humoral immune responses are characterized by complex mixtures of polyclonal antibody
species varying in their isotype, target epitope specificity and affinity. Posttranslational …
species varying in their isotype, target epitope specificity and affinity. Posttranslational …
GlYcoLISA: antigen-specific and subclass-specific IgG Fc glycosylation analysis based on an immunosorbent assay with an LC–MS readout
Immunoglobulin G (IgG) fragment crystallizable (Fc) glycosylation modulates effector
functions such as antibody-dependent cellular cytotoxicity and complement-dependent …
functions such as antibody-dependent cellular cytotoxicity and complement-dependent …
Platelet transfusion refractoriness due to HLA alloimmunization: Evolving paradigms in mechanisms and management
SR Panch, L Guo, R Vassallo - Blood Reviews, 2023 - Elsevier
Platelet transfusion refractoriness due HLA alloimmunization presents a significant medical
problem, particularly among multiply transfused patients with hematologic malignancies and …
problem, particularly among multiply transfused patients with hematologic malignancies and …
Cellular surface plasmon resonance-based detection of anti-HPA-1a antibody glycosylation in fetal and neonatal alloimmune thrombocytopenia
Z Szittner, AEH Bentlage, AR Temming… - Frontiers in …, 2023 - frontiersin.org
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) can occur due to maternal IgG
antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate …
antibodies targeting platelet antigens, causing life-threatening bleeding in the neonate …
Phagocytosis of platelets opsonized with differently glycosylated anti-HLA hIgG1 by monocyte-derived macrophages
TLJ van Osch, J Steuten, J Nouta, CAM Koeleman… - Platelets, 2023 - Taylor & Francis
Immune-mediated platelet refractoriness (PR) remains a significant problem in the setting of
platelet transfusion and is predominantly caused by the presence of alloantibodies directed …
platelet transfusion and is predominantly caused by the presence of alloantibodies directed …
The role of clinical glyco (proteo) mics in precision medicine
Y van der Burgt, M Wuhrer - Molecular & Cellular Proteomics, 2023 - ASBMB
Glycoproteomics reveals site-specific O-and N-glycosylation that may influence protein
properties including binding, activity, and half-life. The increasingly mature toolbox with …
properties including binding, activity, and half-life. The increasingly mature toolbox with …
In vitro characterization of rare anti-αIIbβ3 isoantibodies produced by patients with Glanzmann thrombasthenia that severely block fibrinogen binding and generate …
CSM Lee, Y Huguenin, X Pillois, M Moulieras… - Research and Practice …, 2024 - Elsevier
Background Glanzmann thrombasthenia (GT) is a rare bleeding disorder caused by
inherited defects of the platelet α IIb β 3 integrin. Platelet transfusions can be followed by an …
inherited defects of the platelet α IIb β 3 integrin. Platelet transfusions can be followed by an …
[HTML][HTML] The impact of pretransplant suspected HLA antibody on the long-term outcome of the graft kidney: A retrospective cohort study
BQ Yang, YJ Bai, LL Wang, B Dai, YM Li, Y Tao… - Transplant …, 2024 - Elsevier
Introduction The preoperative examination of kidney transplantation includes HLA antibody
screening to initially determine the presence of preexisting donor-specific antibody (DSA) …
screening to initially determine the presence of preexisting donor-specific antibody (DSA) …