In vitro cell cultures are an important tool for obtaining insights into cellular processes in an
isolated system and a supplement to in vivo animal experiments. While primary dissociated …

The amyloid-β peptide (Aβ) is widely considered to be the major toxic agent in the
pathogenesis of Alzheimer's disease, a condition which afflicts approximately 36 million …

Difficult to measure accurately and deal with effectively, organic pollutants continue to be a
major hazard in the environment. Significantly expanded, the second edition of Organic …

Astrocytic glutamate transporters are considered an important target for neuroprotective
therapies as the function of these transporters is abnormal in stroke and other neurological …

Among a panel of histone deacetylase (HDAC) inhibitors investigated, suberoylanilide
hydroxamic acid (SAHA) evolved as a potent and non‐toxic candidate drug for the treatment …

Functional precision medicine platforms are emerging as promising strategies to improve
pre-clinical drug testing and guide clinical decisions. We have developed an organotypic …

Organotypic hippocampal slice cultures represent a feasible model for studies of cerebral
ischemia and the role of ionotropic glutamate receptors in oxygen–glucose deprivation …

Toxicity testing with animals is expensive, ethically controversial, and not always predictive
of the human response. Cell-based assays are regarded as an alternative. However …

Objective Inhibitors of the voltage‐gated K+ channel Kv1. 3 are currently in development as
immunomodulators for the treatment of autoimmune diseases. As Kv1. 3 is also expressed …

Atlas of the Neonatal Rat Brain provides photographic, histological illustrations of the
anatomical features of the neonatal rat brain at postnatal (P) days P-1, P-7, and P-14. The …