Metabolic flexibility has emerged as a critical determinant of CD8+ T-cell antitumor activity,
yet the mechanisms driving the metabolic flexibility of T cells have not been determined. In …

Simple Summary Tumors escape from the host immune control by upregulation of inhibitory
immune checkpoints. Immune checkpoint inhibition (ICI) has become the standard of care …

Chemoimmunotherapy can boost strong antitumor immune responses by triggering
immunogenic cell death (ICD), which highlights a promising prospect in clinical applications …

Myeloid-derived suppressor cells (MDSCs), major components maintaining the immune
suppressive microenvironment in lung cancer, are relevant to the invasion, metastasis, and …

Chronic Human Immunodeficiency Virus (HIV) infection remains a significant challenge to
global public health. Despite advances in antiretroviral therapy (ART), which has …

Patients with colorectal cancer (CRC) suffer from poor prognosis and lack effective drugs.
Dihydroartemisinin (DHA) has anti-cancer potential but the mechanism remains unclear. We …

The maintenance of antigen-specific CD8+ T cells underlies the efficacy of vaccines and
immunotherapies. Pathways contributing to CD8+ T cell loss are not completely understood …

Ginger extract (GE) and its major component 6‐gingerol (6G) have been reported to exert
anti‐tumor effects in various cancers. The underlying mechanism, however, has not been …

Adaptive immune cells prevent solid tumor progression by targeting and killing tumor cells.
However, there are no comprehensive studies on peripheral circulating adaptive immune …

Background Colorectal cancer is the second leading cause of cancer-related deaths, which
imposes a significant societal burden. Regular screening and emerging molecular tumor …