This manuscript reviews the reasons why Integrase inhibitors should now routinely
constitute a part of first line antiretroviral therapy for the treatment of HIV disease. The use of …

Abstract Background South Africa has the largest public antiretroviral therapy (ART)
programme in the world. We assessed temporal trends in pretreatment HIV-1 drug …

Abstract Background South Africa, with one of the highest HIV prevalences in the world,
introduced the universal test and treat (UTT) programme in September 2016. Barriers to …

Introduction As antiretroviral therapy (ART) is scaled up, more patients become eligible for
routine viral load (VL) monitoring, the most important tool for monitoring ART efficacy. For …

To investigate the prevalence and temporal trend of transmitted drug resistance (TDR), a
nationwide cross-sectional survey was conducted among 5627 ART naïve newly diagnosed …

Background In order to assess the level of transmitted and/or pre-treatment antiretroviral
drug resistance to HIV-1, the World Health Organization (WHO) recommends that regular …

Abstract Background KwaZulu-Natal (KZN) Province in South Africa has the highest HIV
disease burden in the country, with an estimated population prevalence of 24.7%. A pilot …

Objective: To estimate the prevalence of HIV drug resistance over time and identify risk
factors for multiclass resistance. Design: Prospective clinical cohort of HIV-infected patients …

ABSTRACT Background: Traditional health practitioners (THPs) have been identified as a
key local resource in the fight against human immunodeficiency virus/acquired immune …

There is evidence of increasing levels of pretreatment HIV drug resistance (PDR) in
Southern Africa. We used data from two large population-based HIV surveillance studies to …