The solute carrier 6 (SLC6) family of the human genome comprises transporters for
neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family …

Since the late 1970s glycine has been considered an important inhibitory neurotransmitter in
brain stem and medulla. The description of its involvement in the mechanism of action of the …

Schizophrenia is a highly debilitating mental disorder which afflicts approximately 1% of the
global population. Cognitive and negative deficits account for the lifelong disability …

The NMDA receptor is thought to play a central role in some forms of neuronal plasticity,
including the induction of long-term potentiation. NMDA receptor hypofunction can result in …

Ionotropic AMPA and NMDA glutamate receptors are ligand-gated ion channels that
mediate fast synaptic transmission in the brain and play a crucial role in learning and …

Epilepsy, one of the most prevalent neurological conditions, presents as a complex disorder
of network homeostasis characterized by spontaneous non-provoked seizures and …

Background Lidocaine exerts antinociceptive effects when applied systemically. The
mechanisms are not fully understood but glycinergic mechanisms might be involved. The …

Patients with chronic pain often have accompanying cognitive deficiency, which may reduce
their quality of life and hamper efficient medical treatment. Alteration of extracellular glycine …

Glycine plays two roles in neurotransmission. In caudal areas like the spinal cord and the
brainstem, it acts as an inhibitory neurotransmitter, but in all regions of the CNS, it also works …

Multiple lines of evidence indicate that hypofunction of glutamatergic neurotransmission via
N-methyl-D-aspartate (NMDA) receptors might be implicated in the pathophysiology of …