Since the introduction of insulin almost a century ago, more than 80 peptide drugs have
reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis …

Safety and efficacy constitute the major criteria governing regulatory approval of any new
drug. The best method to maximize safety and efficacy is to deliver a proven therapeutic …

Over the last 3 decades, monoclonal antibodies have become the most important class of
therapeutic biologicals on the market. Development of therapeutic antibodies was …

Phage display is the technology that allows expression of exogenous (poly) peptides on the
surface of phage particles. The concept is simple in principle: a library of phage particles …

In the last two decades, protein–protein interactions (PPIs) have been used as the main
target for drug development. However, with larger or superficial binding sites, it has been …

To cite this article: Cicardi M, Bork K, Caballero T, Craig T, Li HH, Longhurst H, Reshef A,
Zuraw B on behalf of HAWK (Hereditary Angioedema International Working Group) …

Antimicrobial peptides are small molecules with activity against bacteria, yeasts, fungi,
viruses, bacteria, and even tumor cells that make these molecules attractive as therapeutic …

Antibodies have been the paradigm of binding proteins with desired specificities for more
than one century and during the past decade their recombinant or humanized versions have …

Background Hereditary angioedema is a rare genetic disorder characterized by acute,
intermittent, and potentially life-threatening attacks of edema of the skin and mucosa. We …

Phage display, the presentation of (poly) peptides as fusions to capsid proteins on the
surface of bacterial viruses, celebrates its 25th birthday in 2010. The technique, coupled with …